INT289518

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Arc, Sirt1) nucleoplasm (Sirt1) endosome (Arc)
nuclear envelope (Sirt1) histone binding (Sirt1) enzyme binding (Sirt1)
Arc (Rattus norvegicus)
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 35.68 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 22 100.00 Very High Very High Very High
Weight Gain 4 84.44 Quite High
Body Weight Changes 1 75.56 Quite High
Body Weight 17 73.52 Quite High
Obesity 5 17.76 Low Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Appetite Loss 5 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Metabolic Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm the specificity of pharmacological Sirt1 inhibition, and to observe whether the acute manipulation of Sirt1 activity could be recapitulated in the long-term, we knocked down Sirt1 expression by infusing Sirt1 specific siRNAs directly into the ARC (Figure S1F).
ARC Regulation (infusing) of Sirt1 associated with aids-related complex
1) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.56 Pain Relevance 0

General Comments

This test has worked.

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