INT28952

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Context Info
Confidence 0.58
First Reported 1985
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 75
Total Number 82
Disease Relevance 41.11
Pain Relevance 12.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
cartilage 12
liver 8
chondrocytes 6
PGE2 6
stems 6
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 31 100.00 Very High Very High Very High
Inflammation 622 99.98 Very High Very High Very High
Arthritis 128 99.84 Very High Very High Very High
Osteoarthritis 301 99.44 Very High Very High Very High
cytokine 178 99.40 Very High Very High Very High
Somatostatin 187 99.22 Very High Very High Very High
antagonist 62 98.80 Very High Very High Very High
Fibrositis 107 98.48 Very High Very High Very High
addiction 3 97.66 Very High Very High Very High
Neurotransmitter 19 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 800 100.00 Very High Very High Very High
INFLAMMATION 635 99.98 Very High Very High Very High
Magnesium Deficiency 2 99.90 Very High Very High Very High
Juvenile Chronic Polyarthritis 8 99.84 Very High Very High Very High
Diabetes Mellitus 113 99.66 Very High Very High Very High
Sickle Cell Anemia 29 99.64 Very High Very High Very High
Arthritis 139 99.62 Very High Very High Very High
Disease 543 99.52 Very High Very High Very High
Osteoarthritis 312 99.44 Very High Very High Very High
Syndrome 49 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, only the high OA group showed a significant inhibition of IGF-1 production when PGE2 synthesis was reduced with Naproxen, a non-steroidal antiinflammatory drug (NSAID) that inhibits cyclooxygenases (COX).
Negative_regulation (inhibition) of Gene_expression (production) of IGF-1 in PGE2 associated with inflammation, cinod and osteoarthritis
1) Confidence 0.58 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.55 Pain Relevance 0.69
Concomitant with a suppression of local, autocrine production of IGF-1 during inflammation is an uncoupling of the signal transduction pathways for exogenous Growth Hormone (GH) and IGF-1 [34-36].
Negative_regulation (suppression) of Gene_expression (production) of IGF-1 associated with inflammation
2) Confidence 0.58 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.62 Pain Relevance 0.31
(5 ng/ml) exposed explants displayed a complete suppression of IGF-1 production (Figure 3).
Negative_regulation (suppression) of Gene_expression (production) of IGF-1
3) Confidence 0.58 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.09 Pain Relevance 0.09
Indeed, there appears to be excellent evidence that growth restriction with chronic inflammation, including arthritis, is the result of suppression of IGF-1 production and activity, independent of GH, and in response to IL-6 [41,42].
Negative_regulation (suppression) of Gene_expression (production) of IGF-1 associated with inflammation and arthritis
4) Confidence 0.58 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.52 Pain Relevance 0.21
Profound growth failure despite elevated GH levels in GH receptor deficiency (GHRD) results from reduced insulin-like growth factor-I (IGF-I) synthesis.
Negative_regulation (reduced) of Gene_expression (synthesis) of IGF-I
5) Confidence 0.57 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7686916 Disease Relevance 0.15 Pain Relevance 0.05
Our primary hypotheses were that lycopene supplement would decrease IGF-1 expression and that fish oil supplementation would decrease COX-2 expression, each compared to placebo.
Negative_regulation (decrease) of Gene_expression (expression) of IGF-1
6) Confidence 0.55 Published 2010 Journal Cancer Causes Control Section Body Doc Link PMC3002170 Disease Relevance 0.06 Pain Relevance 0
Accrual of 29 patients to each of the three arms was sufficient to detect a 40% difference in the proportion of patients with a 2-fold decrease in the expression of the IGF-1 gene with lycopene or in the COX-2 gene with fish oil, each compared with placebo, using FisherÂ’s exact test.
Negative_regulation (decrease) of Gene_expression (expression) of IGF-1 in arms
7) Confidence 0.55 Published 2010 Journal Cancer Causes Control Section Body Doc Link PMC3002170 Disease Relevance 0.05 Pain Relevance 0
Canalis and Avioli have postulated that reduced IGF-1 synthesis may be responsible for the inhibition of bone formation caused by steroids [48].
Negative_regulation (reduced) of Gene_expression (synthesis) of IGF-1
8) Confidence 0.53 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.25 Pain Relevance 0
A possible explanation for this unexpected increase in IGF-1 could be that glucocorticoids inhibit the production of IGF-1 in the muscle, followed by a decrease in negative feedback regulation of liver IGF-1, which would increase serum levels of IGF-1 [46].
Negative_regulation (inhibit) of Gene_expression (production) of IGF-1 in liver
9) Confidence 0.53 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.23 Pain Relevance 0
to human cartilage explants at a dose that promotes cartilage catabolism results in a suppression of IGF-1 production (P < 0.05).
Negative_regulation (suppression) of Gene_expression (production) of IGF-1 in cartilage
10) Confidence 0.53 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.23 Pain Relevance 0.17
Inflammation suppresses the local expression of IGF-1 in cartilage [20,26,27,29], as in other tissues [31-34], resulting in a catabolic state and impaired tissue repair [31-36].
Negative_regulation (suppresses) of Gene_expression (expression) of IGF-1 in cartilage associated with inflammation
11) Confidence 0.53 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2131759 Disease Relevance 0.39 Pain Relevance 0.26
The production of IGF-I is suppressed in malnourished patients, as well as in certain disease states, such as liver disease, hypothyroidism, or poorly controlled diabetes.
Negative_regulation (suppressed) of Gene_expression (production) of IGF-I in liver associated with liver disease, diabetes mellitus, thyroid disease and disease
12) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.47 Pain Relevance 0.08
However, these two endocrine systems interact at multiple levels and in diabetes mellitus the GH-IGF-1 axis is grossly disturbed, with increased secretion of GH, reduced plasma levels of IGF-1, and complex tissue-specific changes in IGF binding proteins (IGFBPs).
Negative_regulation (reduced) of Gene_expression (levels) of IGF-1 in plasma associated with diabetes mellitus
13) Confidence 0.43 Published 2002 Journal Treat Endocrinol Section Abstract Doc Link 15832492 Disease Relevance 0.33 Pain Relevance 0
However, this is the first report that IGF-1 production can be maintained in the face of these otherwise completely suppressive signals.
Negative_regulation (maintained) of Gene_expression (production) of IGF-1 in face
14) Confidence 0.43 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.21 Pain Relevance 0.13
While reduced production of GH and IGF-1 are associated with aging and joint dysfunction, poor mobility and increased mortality [36,37,53], the system can be further uncoupled at the level of signal transduction.
Negative_regulation (reduced) of Gene_expression (production) of IGF-1 in joint associated with aging and arthropathy
15) Confidence 0.43 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.20 Pain Relevance 0.03
In these conditions the GH secretion is normal but peripheral effects is compromised with low or very low levels of serum IGF-1, due to a type of GH resistance or more often to alteration of IGF-1 production from the liver.2,10
Negative_regulation (low) of Gene_expression (levels) of IGF-1 in liver
16) Confidence 0.43 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.80 Pain Relevance 0
The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis.
Negative_regulation (inhibition) of Gene_expression (synthesis) of IGF-1 in PGE2
17) Confidence 0.42 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.26 Pain Relevance 0.71
The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis.
Negative_regulation (reduced) of Gene_expression (synthesis) of IGF-1 in PGE2
18) Confidence 0.42 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.18 Pain Relevance 0.67
This age-related decline stems both from the decline of growth hormone, which results in reduced liver IGF-1 production as well as a reduction in the ability of skeletal muscle cells to produce IGF-1 locally.
Negative_regulation (reduced) of Gene_expression (production) of IGF-1 in stems
19) Confidence 0.42 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.26 Pain Relevance 0.08
This age-related decline stems both from the decline of growth hormone, which results in reduced liver IGF-1 production as well as a reduction in the ability of skeletal muscle cells to produce IGF-1 locally.
Negative_regulation (reduction) of Gene_expression (produce) of IGF-1 in stems
20) Confidence 0.42 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.43 Pain Relevance 0.11

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