INT289525

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) transport (Ucp2) mitochondrion (Ucp2)
nuclear envelope (Sirt1) histone binding (Sirt1) enzyme binding (Sirt1)
Anatomy Link Frequency
fat 2
pancreas 2
Sirt1 (Rattus norvegicus)
Ucp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 2 80.64 Quite High
Hippocampus 2 65.12 Quite High
antagonist 10 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Obesity 10 99.96 Very High Very High Very High
Metabolic Disorder 4 85.76 High High
Disease 2 55.92 Quite High
Aging 4 38.64 Quite Low
Aids-related Complex 44 5.00 Very Low Very Low Very Low
Body Weight 34 5.00 Very Low Very Low Very Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Appetite Loss 10 5.00 Very Low Very Low Very Low
Weight Gain 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the adipose tissue, Sirt1 triggers fat mobilization by inhibiting peroxisome proliferator-activated receptor (PPAR-gamma), and in the pancreas repression of the uncoupling protein 2 (UCP2) by Sirt1 increases insulin secretion [1].
Sirt1 Negative_regulation (inhibiting) of in pancreas Negative_regulation (repression) of uncoupling protein 2 in fat associated with repression and obesity
1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.43 Pain Relevance 0.07
In the adipose tissue, Sirt1 triggers fat mobilization by inhibiting peroxisome proliferator-activated receptor (PPAR-gamma), and in the pancreas repression of the uncoupling protein 2 (UCP2) by Sirt1 increases insulin secretion [1].
Sirt1 Negative_regulation (inhibiting) of in pancreas Negative_regulation (repression) of UCP2 in fat associated with repression and obesity
2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.43 Pain Relevance 0.07

General Comments

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