INT289530

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Sirt1, Foxo1) nucleus (Sirt1, Foxo1) nucleoplasm (Sirt1)
nuclear envelope (Sirt1) histone binding (Sirt1) DNA binding (Foxo1)
Sirt1 (Rattus norvegicus)
Foxo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 8 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 22 83.40 Quite High
Aging 5 82.96 Quite High
Heart Disease 2 63.68 Quite High
Coronary Artery Disease 4 61.92 Quite High
Myocardial Reperfusion Injury 1 57.12 Quite High
Cancer 6 34.12 Quite Low
Repression 3 33.76 Quite Low
Targeted Disruption 9 32.20 Quite Low
Injury 4 6.72 Low Low
Colon Cancer 1 6.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SirT1 regulates several transcription factors including FoxO1, which is inactivated by phosphorylation via Akt [32].
SirT1 Regulation (regulates) of FoxO1
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 0.27 Pain Relevance 0
We next tested whether Sirt1 alters FoxO1 activity.
Sirt1 Spec (whether) Regulation (alters) of FoxO1
2) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.

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