INT289531

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) mitochondrion (Acsm3)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Acsm3 (Rattus norvegicus)
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 9 75.80 Quite High
Hyperphagia 1 51.20 Quite High
Body Weight 17 25.68 Quite Low
Weight Gain 4 17.20 Low Low
Aids-related Complex 22 6.80 Low Low
Obesity 5 5.00 Very Low Very Low Very Low
Appetite Loss 5 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Metabolic Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of Sirt1 in N43 cells, by either resveratrol or SA3 resulted in a decrease in the phosphorylation of S6K and its downstream substrates (Figure 5A, Figure 5B, Figure S5 top panels), suggesting that Sirt1 inhibits this pathway in the mTOR signaling.
SA3 Positive_regulation (Activation) of Sirt1
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.27 Pain Relevance 0

General Comments

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