INT289538

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Context Info
Confidence 0.34
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Sirt1, Stat3) nucleolus (Sirt1, Stat3) nucleus (Sirt1, Stat3)
nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
Sirt1 (Rattus norvegicus)
Stat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 70.00 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 17 76.28 Quite High
Aids-related Complex 22 72.16 Quite High
Weight Gain 4 57.16 Quite High
Hyperphagia 1 36.68 Quite Low
Stress 1 5.12 Low Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Obesity 5 5.00 Very Low Very Low Very Low
Appetite Loss 5 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since Stat3 is a positive regulator of POMC transcription, a potential deacetylation of Stat3 by Sirt1 might render Stat3 inactive, leading to POMC downregulation.
Sirt1 Positive_regulation (regulator) of Stat3
1) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.37 Pain Relevance 0.04

General Comments

This test has worked.

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