INT289539

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
enzyme binding (Sirt1) cytoplasm (Sirt1) extracellular space (Agrp)
Sirt1 (Rattus norvegicus)
Agrp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 94.72 High High
addiction 1 76.80 Quite High
Hippocampus 1 21.72 Low Low
Central nervous system 1 14.40 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 5 96.04 Very High Very High Very High
Body Weight 17 91.72 High High
Obesity 5 79.60 Quite High
Aids-related Complex 22 59.44 Quite High
Aging 2 34.72 Quite Low
Disease 1 26.16 Quite Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Weight Gain 4 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Metabolic Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of hypothalamic Sirt1 activity reversed the fasting induced decrease of FoxO1 acetylation, and resulted in increased POMC and decreased AgRP expressions.
Negative_regulation (Inhibition) of Sirt1 Negative_regulation (decreased) of Gene_expression (expressions) of AgRP
1) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.47 Pain Relevance 0.09

General Comments

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