INT289543

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.81
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
nucleolus (Sirt1) nucleus (Sirt1) enzyme binding (Sirt1)
Anatomy Link Frequency
diencephalons 2
AtT20 2
body 2
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 2 80.52 Quite High
Kinase C 10 74.76 Quite High
Bioavailability 5 68.48 Quite High
antagonist 27 45.52 Quite Low
addiction 4 27.60 Quite Low
Inflammation 5 8.08 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 68 98.80 Very High Very High Very High
Stress 19 96.24 Very High Very High Very High
Aids-related Complex 88 95.00 High High
Congenital Anomalies 12 87.68 High High
Diabetes Mellitus 29 86.08 High High
Uterine Fibroids 1 73.44 Quite High
Coronary Heart Disease 1 72.24 Quite High
Diabetes Complications 3 71.32 Quite High
Obesity 27 67.80 Quite High
Body Weight Changes 4 53.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next wanted to determine if modulating Sirt1 activity or its expression would effect food intake and body weight of adult rats.
Spec (determine) Regulation (modulating) of Gene_expression (expression) of Sirt1 in body associated with body weight
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.52 Pain Relevance 0
In support of these in vivo studies, we also analyzed the effect of Sirt1 expression on POMC in primary hypothalamic cultures obtained from E17.5 rat embryo diencephalons [21], [25].
Spec (analyzed) Regulation (effect) of Spec (analyzed) Gene_expression (expression) of Sirt1 in diencephalons
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.24 Pain Relevance 0
To study the regulation of POMC expression by Sirt1, we used the AtT20 cell line that has been shown to be a useful in vitro model for this type of studies [26], [27].
Regulation (regulation) of Gene_expression (expression) of Sirt1 in AtT20
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.14 Pain Relevance 0
Overexpression or activation of SIRT1, an NAD+ -dependent protein deacetylase, is sensitive to oxidative signals by drug interventions and significantly reduces the status of oxidative stress.30
Regulation (sensitive) of Gene_expression (Overexpression) of SIRT1 associated with stress
4) Confidence 0.41 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.69 Pain Relevance 0.11
When the Sirt1 expression was knocked down by a Sirt1 shRNA adenovirus (Figure S3B), the ?
Regulation (knocked) of Gene_expression (expression) of Sirt1
5) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.21 Pain Relevance 0

General Comments

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