INT289546

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.10
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
nucleolus (Sirt1) nucleus (Sirt1) enzyme binding (Sirt1)
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 5 84.80 Quite High
Calcium channel 4 82.08 Quite High
Central nervous system 5 77.48 Quite High
Kinase C 20 76.32 Quite High
Bioavailability 10 70.04 Quite High
antagonist 39 40.24 Quite Low
addiction 5 25.28 Quite Low
Inflammation 10 9.64 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 35 99.00 Very High Very High Very High
Aids-related Complex 110 98.84 Very High Very High Very High
Aging 22 97.80 Very High Very High Very High
Congenital Anomalies 24 93.20 High High
Diabetes Mellitus 58 91.60 High High
Disease 9 89.24 High High
Weight Gain 20 81.20 Quite High
Uterine Fibroids 2 78.96 Quite High
Targeted Disruption 45 75.08 Quite High
Coronary Heart Disease 2 73.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anti-Sirt1 antibody in blocking solution was then added (1?
Negative_regulation (blocking) of Gene_expression (antibody) of Sirt1
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.24 Pain Relevance 0
Fasting induced decrease in p53 acetylation [10] was also reversed by inhibition of Sirt1 function, and Stat3 acetylation was insensitive to Sirt1 inhibition (data not shown).
Negative_regulation (inhibition) of Gene_expression (function) of Sirt1
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.16 Pain Relevance 0
Consequently, Sirt1 expression was knocked-down 40% at the protein level (Figure S1E), which was confirmed by the decreased number of Sirt1 positive ARC nuclei (Figure S1F, G).
Negative_regulation (knocked) of Gene_expression (expression) of Sirt1 associated with aids-related complex
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.56 Pain Relevance 0
Since hypothalamic Sirt1 regulates food intake through melanocortin receptors (Figure 1C), we investigated the effect of inhibition of hypothalamic Sirt1 in POMC and AgRP expression.
Spec (investigated) Negative_regulation (inhibition) of Gene_expression (expression) of Sirt1
4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.29 Pain Relevance 0
ROS activate p38 kinase, which further promotes ROS generation, forming a positive feedback loop to sustain ROS-p38 kinase signaling, which may associate with a reduction in SIRT1 protein expression.
Negative_regulation (reduction) of Gene_expression (expression) of SIRT1
5) Confidence 0.39 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.71 Pain Relevance 0.11
This situation (at the gene expression level) can be reversed by specific over expression of central Sirt1 [8].
Negative_regulation (reversed) of Gene_expression (expression) of Sirt1
6) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.37 Pain Relevance 0.08
Overexpression or activation of SIRT1, an NAD+ -dependent protein deacetylase, is sensitive to oxidative signals by drug interventions and significantly reduces the status of oxidative stress.30
Negative_regulation (reduces) of Gene_expression (Overexpression) of SIRT1 associated with stress
7) Confidence 0.29 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.77 Pain Relevance 0.11

General Comments

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