INT289547

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.76
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
nucleolus (Sirt1) nucleus (Sirt1) enzyme binding (Sirt1)
Anatomy Link Frequency
hypothalamus 2
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 2 80.52 Quite High
Kinase C 10 74.76 Quite High
Bioavailability 5 68.48 Quite High
Inflammation 5 8.08 Low Low
antagonist 12 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 16 95.68 Very High Very High Very High
Congenital Anomalies 12 86.56 High High
Diabetes Mellitus 29 84.96 Quite High
Uterine Fibroids 1 72.32 Quite High
Coronary Heart Disease 1 72.24 Quite High
Diabetes Complications 3 71.32 Quite High
Parkinson's Disease 1 49.32 Quite Low
Aids-related Complex 22 48.72 Quite Low
Hepatopulmonary Syndrome 1 44.64 Quite Low
Hyperglycemia 9 43.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They proposed that resveratrol induced food intake by activating AMPK via Sirt1 activation in the hypothalamus.
Positive_regulation (activating) of Positive_regulation (activation) of Sirt1 in hypothalamus
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.08 Pain Relevance 0
Overexpression or activation of SIRT1, an NAD+ -dependent protein deacetylase, is sensitive to oxidative signals by drug interventions and significantly reduces the status of oxidative stress.30
Positive_regulation (Overexpression) of Positive_regulation (activation) of dependent protein deacetylase associated with stress
2) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.69 Pain Relevance 0.11

General Comments

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