INT289550

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 25
Total Number 29
Disease Relevance 13.59
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
nucleolus (Sirt1) nucleus (Sirt1) enzyme binding (Sirt1)
Anatomy Link Frequency
hypothalamus 3
plasma 1
fat 1
internal 1
adipose tissue 1
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 20 98.32 Very High Very High Very High
antagonist 114 97.20 Very High Very High Very High
Central nervous system 20 95.44 Very High Very High Very High
Inflammatory response 3 87.92 High High
Kinase C 21 85.20 High High
Calcium channel 4 79.80 Quite High
addiction 20 79.28 Quite High
Bioavailability 13 67.76 Quite High
Inflammation 19 58.08 Quite High
fibrosis 47 23.52 Low Low
Disease Link Frequency Relevance Heat
Aging 61 100.00 Very High Very High Very High
Hyperphagia 20 99.98 Very High Very High Very High
Myocardial Infarction 246 99.46 Very High Very High Very High
Weight Gain 80 99.44 Very High Very High Very High
Repression 26 99.22 Very High Very High Very High
Apoptosis 158 98.88 Very High Very High Very High
Aids-related Complex 440 98.52 Very High Very High Very High
Appetite Loss 100 98.52 Very High Very High Very High
Obesity 120 96.52 Very High Very High Very High
Death 12 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been recently shown in mice that hypothalamic Sirt1 protein levels are increased by fasting [10].
Positive_regulation (increased) of Sirt1
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.31 Pain Relevance 0
They proposed that resveratrol induced food intake by activating AMPK via Sirt1 activation in the hypothalamus.
Positive_regulation (activation) of Sirt1 in hypothalamus
2) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.07 Pain Relevance 0
Fasting increased hypothalamic NAD+ levels and Sirt1 protein content.
Positive_regulation (increased) of Sirt1
3) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.45 Pain Relevance 0.09
In this study, we present data supporting the hypothesis that fasting induced hyperphagia requires hypothalamic Sirt1 activity.
Positive_regulation (requires) of Sirt1 associated with hyperphagia
4) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.38 Pain Relevance 0
The fasting induced increase in hypothalamic Sirt1 protein level was probably due to post-transcriptional regulations, because Sirt1 mRNA level was unaltered by fasting (data not shown).
Positive_regulation (increase) of Sirt1
5) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0
However, upon fasting, ARC FoxO1 acetylation decreases in a Sirt1 dependent manner (Figure 4B), and Sirt1 cofactor NAD+ and Sirt1 protein levels increase (Figure 2), accounting for the increased Sirt1 activity (Figure 4A, B).
Positive_regulation (increase) of Sirt1 associated with aids-related complex
6) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0
However, upon fasting, ARC FoxO1 acetylation decreases in a Sirt1 dependent manner (Figure 4B), and Sirt1 cofactor NAD+ and Sirt1 protein levels increase (Figure 2), accounting for the increased Sirt1 activity (Figure 4A, B).
Positive_regulation (increase) of Sirt1 associated with aids-related complex
7) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.24 Pain Relevance 0
Furthermore we showed that increased Sirt1 protein in the remote area was associated with deacetylation of the Sirt1-target p53 in GK + MI rats.
Positive_regulation (increased) of Sirt1 protein associated with myocardial infarction
8) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.89 Pain Relevance 0
According to our results, however apoptosis was increased in the GK + MI rat heart in spite of the increased Sirt1-p53 deacetylation, although modestly with only 0.20% TUNEL-positive cells in the border zone of GK + MI rats.
Positive_regulation (increased) of Sirt1 in heart associated with apoptosis and myocardial infarction
9) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.28 Pain Relevance 0.03
In the adipose tissue, Sirt1 triggers fat mobilization by inhibiting peroxisome proliferator-activated receptor (PPAR-gamma), and in the pancreas repression of the uncoupling protein 2 (UCP2) by Sirt1 increases insulin secretion [1].
Positive_regulation (increases) of Sirt1 in adipose tissue associated with repression and obesity
10) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.41 Pain Relevance 0.07
Brain Sirt1 expression increases by caloric restriction [9], and fasting was shown to increase brain Sirt1 protein content specifically in the hypothalamus [10].
Positive_regulation (increase) of Sirt1 in hypothalamus
11) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.36 Pain Relevance 0.08
For example, in the liver, the Sirt1 protein level increases upon fasting [3] and decreases by high fat diet [4].
Positive_regulation (increases) of Sirt1 in fat
12) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.45 Pain Relevance 0.09
This conclusion is consistent with the observation that Sirt1 protein levels and activity were increasing in fasted mouse [10] and rat hypothalamus.
Positive_regulation (increasing) of Sirt1 in hypothalamus
13) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.41 Pain Relevance 0
However, upon fasting, ARC FoxO1 acetylation decreases in a Sirt1 dependent manner (Figure 4B), and Sirt1 cofactor NAD+ and Sirt1 protein levels increase (Figure 2), accounting for the increased Sirt1 activity (Figure 4A, B).
Positive_regulation (increase) of Sirt1 associated with aids-related complex
14) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0
For example, increased nuclear NAD biosynthesis and Sirt1 activation are linked to axonal protection [5], and hippocampus over expression of Sirt1 provides protection against neurodegeneration in a mouse model of Alzheimer's disease [6].
Positive_regulation (activation) of Sirt1 in hippocampus associated with hippocampus and disease
15) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.45 Pain Relevance 0.10
Induction of hypothalamic Sirt1 activity by ICV infusion of SA3 to re-fed rats (Figure S1D, right panel) resulted in increased short-term food intake (Figure 1A, right).
Positive_regulation (Induction) of Sirt1
16) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.58 Pain Relevance 0
As shown in Figure 1D, inhibition of hypothalamic Sirt1 resulted in a significant rise in plasma T3 and T4 levels, strongly suggesting that the melanocortin system was positively activated when Sirt1 activity was inhibited.


Positive_regulation (activated) of Sirt1 in plasma
17) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.35 Pain Relevance 0
Total RNA (1 µg) isolated (Trizol Reagent, Invitrogen) from fresh arcuate nucleus tissue was converted to cDNA and used to screen expression levels of Sirt1, POMC, AgRP, and tubulin (internal control).
Positive_regulation (screen) of Sirt1 in internal
18) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.07 Pain Relevance 0
Higher NAD+ levels, in addition to an elevated hypothalamic Sirt1 protein expression, suggest that Sirt1 deacetylase activity increases upon fasting.
Positive_regulation (increases) of Sirt1
19) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.30 Pain Relevance 0
Since fasting was reported to modulate hypothalamic S6K activity, we further analyzed whether fasting induced hypothalamic Sirt1 activity was involved in this regulation.
Spec (whether) Positive_regulation (induced) of Sirt1
20) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.30 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox