INT289551

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.46
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
nucleolus (Sirt1) nucleus (Sirt1) enzyme binding (Sirt1)
Anatomy Link Frequency
hypothalamus 1
brain 1
heart 1
body 1
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 8 89.48 High High
Central nervous system 8 82.16 Quite High
fibrosis 14 80.72 Quite High
antagonist 40 68.36 Quite High
addiction 8 27.60 Quite Low
anesthesia 19 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 16 99.84 Very High Very High Very High
Metabolic Disorder 16 97.80 Very High Very High Very High
Body Weight 136 97.72 Very High Very High Very High
Diabetes Mellitus 55 97.08 Very High Very High Very High
Obesity 41 96.64 Very High Very High Very High
Disease 8 93.92 High High
Aids-related Complex 176 93.12 High High
Weight Gain 32 92.04 High High
Myocardial Infarction 78 85.04 High High
Stress 16 84.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is very likely that Sirt1 mediated regulation of food intake involves multiple pathways, and includes other metabolic sensors such as AMPK, or mTOR.
Regulation (regulation) of Sirt1
1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.07 Pain Relevance 0
At a global scale Sirt1 target genes in the mouse brain are deregulated by aging.
Regulation (deregulated) of Sirt1 in brain associated with aging
2) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.48 Pain Relevance 0.09
Also, the fasting induced decrease in POMC expression and increase in AgRP expression were sensitive to Sirt1 enzymatic activity (Figure 3A, B).
Regulation (sensitive) of Sirt1
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.24 Pain Relevance 0
Altogether, the in vivo combined with the in vitro results strongly supports an inhibitory role for Sirt1 on POMC gene regulation in a pre-translational manner.


Regulation (regulation) of Sirt1
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.15 Pain Relevance 0
We next wanted to determine if modulating Sirt1 activity or its expression would effect food intake and body weight of adult rats.
Spec (determine) Regulation (modulating) of Sirt1 in body associated with body weight
5) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.52 Pain Relevance 0
The fasting induced increase in hypothalamic Sirt1 protein level was probably due to post-transcriptional regulations, because Sirt1 mRNA level was unaltered by fasting (data not shown).
Regulation (unaltered) of Sirt1
6) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0
Given the role of Sirt1 in several peripheral tissues and hypothalamus, potential therapies centered on Sirt1 regulation might provide promising therapies in the treatment of metabolic diseases including obesity.



Regulation (regulation) of Sirt1 in hypothalamus associated with metabolic disorder and obesity
7) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2790615 Disease Relevance 0.60 Pain Relevance 0.03
In the present study our results further showed that another Sirt1- target, FOXO3a was dephosphorylated, possibly due to Akt-kinase dephosphorylation in the diabetic GK rat heart.
Regulation (target) of Sirt1 in heart associated with diabetes mellitus
8) Confidence 0.26 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.60 Pain Relevance 0.08
To confirm the specificity of pharmacological Sirt1 inhibition, and to observe whether the acute manipulation of Sirt1 activity could be recapitulated in the long-term, we knocked down Sirt1 expression by infusing Sirt1 specific siRNAs directly into the ARC (Figure S1F).
Regulation (specificity) of Sirt1 associated with aids-related complex
9) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.55 Pain Relevance 0

General Comments

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