INT289553

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 20.43
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
nucleolus (Sirt1) nucleus (Sirt1) enzyme binding (Sirt1)
Anatomy Link Frequency
heart 6
hypothalamus 4
cardiomyocytes 2
posterior 2
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 54 92.36 High High
fibrosis 170 90.80 High High
Hippocampus 8 82.20 Quite High
Calcium channel 4 80.52 Quite High
Inflammation 46 74.92 Quite High
Central nervous system 8 74.88 Quite High
Kinase C 20 74.76 Quite High
Bioavailability 10 68.48 Quite High
addiction 8 28.32 Quite Low
anesthesia 52 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 936 99.72 Very High Very High Very High
Hypertrophy 170 99.44 Very High Very High Very High
Diabetes Mellitus 718 99.12 Very High Very High Very High
Apoptosis 488 98.92 Very High Very High Very High
Stress 134 98.64 Very High Very High Very High
Aids-related Complex 176 96.96 Very High Very High Very High
Hyperphagia 8 96.20 Very High Very High Very High
Aging 28 95.20 Very High Very High Very High
Appetite Loss 40 93.68 High High
Fibrosis 146 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Higher NAD+ levels, in addition to an elevated hypothalamic Sirt1 protein expression, suggest that Sirt1 deacetylase activity increases upon fasting.
Positive_regulation (elevated) of Gene_expression (expression) of Sirt1
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.31 Pain Relevance 0
This conclusion is consistent with the observation that Sirt1 protein levels and activity were increasing in fasted mouse [10] and rat hypothalamus.
Positive_regulation (increasing) of Gene_expression (levels) of Sirt1 in hypothalamus
2) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.41 Pain Relevance 0
Although one study showed that Sirt1 overexpressing mice ate less than wild type animals [44], two other studies reported these mice being hyperphagic [45], [46].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Sirt1
3) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0
We showed that Sirt1 protein overexpression is sustained after MI in diabetic rats, and that is localized to the nuclei at the infarct area.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Sirt1 protein associated with diabetes mellitus and myocardial infarction
4) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.52 Pain Relevance 0.16
Western blotting showed an increase in Sirt1 protein expression in sham-operated GK rats compared to Wistar with no further increase in Sirt1 protein expression after MI (Figure 6A).
Positive_regulation (increase) of Gene_expression (expression) of Sirt1 protein associated with myocardial infarction
5) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.46 Pain Relevance 0
Sirt1 overexpression has been shown to protect cardiomyocytes from apoptosis, increase cellular stress resistance and cause modest hypertrophy [13,44] suggesting that an increase in Sirt1 protein expression during heart failure may be cardio protective.
Positive_regulation (increase) of Gene_expression (expression) of Sirt1 protein in heart associated with stress, hypertrophy, apoptosis and myocardial infarction
6) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.21 Pain Relevance 0
Western blotting showed an increase in Sirt1 protein expression in sham-operated GK rats compared to Wistar with no further increase in Sirt1 protein expression after MI (Figure 6A).
Neg (no) Positive_regulation (increase) of Gene_expression (expression) of Sirt1 protein associated with myocardial infarction
7) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.40 Pain Relevance 0
Secondly, our results showed that Sirt1 protein was overexpressed in the myocardial tissue of GK rats and that one of the key Sirt1- targets; p53 was deacetylated in the diabetic heart compared to the non-diabetic situation.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Sirt1 protein in heart associated with diabetes mellitus
8) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.84 Pain Relevance 0.09
Sirtuin1 (Sirt1), a class III histone deacetylase (HDAC) has been shown to act as an endogenous inhibitor of apoptosis in cardiac myocytes [13] and Sirt1-mediated deacetylation of DNA-bound histones, p53 and forkhead class O 3a (FOXO3a) have been implicated in the inhibition of apoptosis and promotion of cellular growth [14], our previous study showed that Sirt1 is overexpressed in cardiomyocytes of diabetic Goto-Kakizaki rats [15].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Sirt1 in cardiomyocytes associated with diabetes mellitus and apoptosis
9) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.53 Pain Relevance 0.03
Sirt1 protein overexpression was further associated with a decrease in p53 acetylation in GK rats postligation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Sirt1 protein
10) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.59 Pain Relevance 0.17
Our study showed that Sirt1 protein was overexpressed in both the remote area (posterior wall) and in the infarct area (anterior wall).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Sirt1 protein in posterior
11) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.63 Pain Relevance 0
Western blotting from remote area confirmed the result from our earlier studies [15], that Sirt1 protein was overexpressed in GK rats.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Sirt1 protein
12) Confidence 0.66 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.72 Pain Relevance 0
This effect is mediated, at least in part, by the fasting induced and Sirt1 mediated deacetylation of FoxO1, such that Sirt1 shifts FoxO1's activity to resist the stress of fasting.
Positive_regulation (mediated) of Gene_expression (deacetylation) of Sirt1 associated with stress
13) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0
Sirt1 overexpressing mice have been generated and their physiology has been examined.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Sirt1
14) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.20 Pain Relevance 0
This effect is mediated, at least in part, by the fasting induced and Sirt1 mediated deacetylation of FoxO1, such that Sirt1 shifts FoxO1's activity to resist the stress of fasting.
Positive_regulation (induced) of Gene_expression (deacetylation) of Sirt1 associated with stress
15) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0
Sirt1 overexpression has been shown to protect cardiomyocytes from apoptosis, increase cellular stress resistance and cause modest hypertrophy [13,44] suggesting that an increase in Sirt1 protein expression during heart failure may be cardio protective.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Sirt1 in heart associated with stress, hypertrophy, apoptosis and myocardial infarction
16) Confidence 0.47 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.01 Pain Relevance 0
Overexpression or activation of SIRT1, an NAD+ -dependent protein deacetylase, is sensitive to oxidative signals by drug interventions and significantly reduces the status of oxidative stress.30
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of SIRT1 associated with stress
17) Confidence 0.47 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.67 Pain Relevance 0.11
We also showed that fasting increases hypothalamic Sirt1 expression and decreases FoxO1 (Forkhead transcription factor) acetylation suggesting that Sirt1 regulates the central melanocortin system in a FoxO1 dependent manner.
Positive_regulation (increases) of Gene_expression (expression) of Sirt1
18) Confidence 0.46 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2790615 Disease Relevance 0.50 Pain Relevance 0.05
Brain Sirt1 expression increases by caloric restriction [9], and fasting was shown to increase brain Sirt1 protein content specifically in the hypothalamus [10].
Positive_regulation (increases) of Gene_expression (expression) of Sirt1 in hypothalamus
19) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.36 Pain Relevance 0.08
Furthermore, increased Sirt1 protein expression was associated with decreased p53 acetylation, and phosphorylation of p38 was increased in diabetic rats with MI.


Positive_regulation (associated) of Gene_expression (expression) of Sirt1 protein associated with diabetes mellitus and myocardial infarction
20) Confidence 0.44 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.83 Pain Relevance 0.12

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