INT289554

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.32
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agrp)
Anatomy Link Frequency
ARC 4
Agrp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 15 100.00 Very High Very High Very High
anesthesia 8 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 156 100.00 Very High Very High Very High
Weight Gain 12 89.04 High High
Body Weight 61 88.32 High High
Obesity 37 75.00 Quite High
Stress 3 70.72 Quite High
Hyperphagia 5 68.56 Quite High
Appetite Loss 17 39.00 Quite Low
Targeted Disruption 29 17.04 Low Low
Decapitation 6 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AgRP, on the other hand, is a strong antagonist of the melanocortin receptors, and blocks ?
Regulation (strong) of Gene_expression (antagonist) of AgRP associated with antagonist
1) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.50 Pain Relevance 0.05
In contrast, knocking down Arc Fto expression by 40% increases food intake by 16%. mRNA levels of Agrp, Pomc and Npy, ARC-expressed genes classically associated with the control of food intake, were not affected by the manipulation of Fto expression.
Neg (not) Regulation (affected) of Gene_expression (expressed) of Agrp in ARC associated with aids-related complex
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.65 Pain Relevance 0
In contrast, knocking down Arc Fto expression by 40% increases food intake by 16%. mRNA levels of Agrp, Pomc and Npy, ARC-expressed genes classically associated with the control of food intake, were not affected by the manipulation of Fto expression.
Regulation (associated) of Gene_expression (expressed) of Agrp in ARC associated with aids-related complex
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.65 Pain Relevance 0
Since hypothalamic Sirt1 regulates food intake through melanocortin receptors (Figure 1C), we investigated the effect of inhibition of hypothalamic Sirt1 in POMC and AgRP expression.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of AgRP
4) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.29 Pain Relevance 0
Also, the fasting induced decrease in POMC expression and increase in AgRP expression were sensitive to Sirt1 enzymatic activity (Figure 3A, B).
Regulation (sensitive) of Gene_expression (expression) of AgRP
5) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.24 Pain Relevance 0

General Comments

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