INT289567

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
nucleolus (Sirt1) nucleus (Sirt1) enzyme binding (Sirt1)
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 10 99.32 Very High Very High Very High
addiction 2 80.72 Quite High
Hippocampus 2 25.64 Quite Low
Central nervous system 2 18.32 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 10 99.98 Very High Very High Very High
Body Weight 34 95.64 Very High Very High Very High
Aids-related Complex 44 93.80 High High
Obesity 10 60.80 Quite High
Aging 4 38.64 Quite Low
Disease 2 30.08 Quite Low
Repression 2 6.40 Low Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Weight Gain 8 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blocking the melanocortin receptors with the melanocortin antagonist SHU9119 attenuated the anorectic effect of Sirt1 inhibition.
Regulation (effect) of Negative_regulation (inhibition) of Sirt1 associated with appetite loss and antagonist
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.45 Pain Relevance 0.09
Since hypothalamic Sirt1 regulates food intake through melanocortin receptors (Figure 1C), we investigated the effect of inhibition of hypothalamic Sirt1 in POMC and AgRP expression.
Spec (investigated) Regulation (effect) of Spec (investigated) Negative_regulation (inhibition) of Sirt1
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.29 Pain Relevance 0

General Comments

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