INT289575

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Context Info
Confidence 0.77
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 47
Total Number 49
Disease Relevance 29.29
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
nucleolus (Sirt1) nucleus (Sirt1) enzyme binding (Sirt1)
Anatomy Link Frequency
hypothalamus 4
heart 3
internal 2
AtT20 2
body 2
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 33 99.88 Very High Very High Very High
Central nervous system 33 92.44 High High
antagonist 179 91.44 High High
fibrosis 184 90.80 High High
addiction 33 88.96 High High
Calcium channel 4 81.56 Quite High
Kinase C 21 79.96 Quite High
Inflammation 49 74.92 Quite High
Bioavailability 10 69.52 Quite High
anesthesia 105 36.12 Quite Low
Disease Link Frequency Relevance Heat
Aids-related Complex 726 100.00 Very High Very High Very High
Targeted Disruption 298 99.88 Very High Very High Very High
Myocardial Infarction 1014 99.72 Very High Very High Very High
Hypertrophy 185 99.20 Very High Very High Very High
Diabetes Mellitus 774 99.12 Very High Very High Very High
Apoptosis 553 98.92 Very High Very High Very High
Body Weight 561 98.80 Very High Very High Very High
Stress 189 98.40 Very High Very High Very High
Repression 33 96.88 Very High Very High Very High
Disease 37 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although one study showed that Sirt1 overexpressing mice ate less than wild type animals [44], two other studies reported these mice being hyperphagic [45], [46].
Gene_expression (overexpressing) of Sirt1
1) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0
For example, increased nuclear NAD biosynthesis and Sirt1 activation are linked to axonal protection [5], and hippocampus over expression of Sirt1 provides protection against neurodegeneration in a mouse model of Alzheimer's disease [6].
Gene_expression (expression) of Sirt1 in hippocampus associated with hippocampus and disease
2) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.45 Pain Relevance 0.10
Using the rat as a physiological in vivo model we found that ablation of Sirt1 activity or knocking-down Sirt1 gene expression at the hypothalamic level resulted in decreased food intake and body weight gain.
Gene_expression (expression) of Sirt1 in body associated with body weight
3) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.34 Pain Relevance 0.09
Sirt1 expression as well as its activity is nutrient sensitive.
Gene_expression (expression) of Sirt1
4) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.40 Pain Relevance 0.08
Although the Sirt1 expression in POMC neurons has been reported [10], its functional role in the hypothalamus has not been determined.
Gene_expression (expression) of Sirt1 in hypothalamus
5) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.32 Pain Relevance 0.09
Sirt1 overexpressing mice have been generated and their physiology has been examined.
Gene_expression (overexpressing) of Sirt1
6) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.20 Pain Relevance 0
Figure S2B shows that Sirt1 is expressed virtually in all POMC neurons in the ARC, in agreement with a previous report [10].
Gene_expression (expressed) of Sirt1 in neurons associated with aids-related complex
7) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.29 Pain Relevance 0
This conclusion is consistent with the observation that Sirt1 protein levels and activity were increasing in fasted mouse [10] and rat hypothalamus.
Gene_expression (levels) of Sirt1 in hypothalamus
8) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.40 Pain Relevance 0
Total RNA (1 µg) isolated (Trizol Reagent, Invitrogen) from fresh arcuate nucleus tissue was converted to cDNA and used to screen expression levels of Sirt1, POMC, AgRP, and tubulin (internal control).
Gene_expression (expression) of Sirt1 in internal
9) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.07 Pain Relevance 0
In support of these in vivo studies, we also analyzed the effect of Sirt1 expression on POMC in primary hypothalamic cultures obtained from E17.5 rat embryo diencephalons [21], [25].
Spec (analyzed) Gene_expression (expression) of Sirt1 in diencephalons
10) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.24 Pain Relevance 0
Brain Sirt1 expression increases by caloric restriction [9], and fasting was shown to increase brain Sirt1 protein content specifically in the hypothalamus [10].
Gene_expression (expression) of Sirt1 in hypothalamus
11) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.36 Pain Relevance 0.08
To confirm the specificity of pharmacological Sirt1 inhibition, and to observe whether the acute manipulation of Sirt1 activity could be recapitulated in the long-term, we knocked down Sirt1 expression by infusing Sirt1 specific siRNAs directly into the ARC (Figure S1F).
Gene_expression (expression) of Sirt1 associated with aids-related complex
12) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.55 Pain Relevance 0
AtT20 cells express Sirt1 (Figure S1B), POMC, and several key transcription factors involved in POMC regulation such as Stat3 and FoxO1 (data not shown).
Gene_expression (express) of Sirt1 in AtT20
13) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.18 Pain Relevance 0
Higher NAD+ levels, in addition to an elevated hypothalamic Sirt1 protein expression, suggest that Sirt1 deacetylase activity increases upon fasting.
Gene_expression (expression) of Sirt1
14) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.30 Pain Relevance 0
However, we detected the 21 kDa proACTH intermediate form (Figure 3C) that showed to increase when the ARC Sirt1 expression was knocked-down by siRNA infusion (Figure S1E).
Gene_expression (expression) of Sirt1 associated with aids-related complex
15) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0
Consequently, Sirt1 expression was knocked-down 40% at the protein level (Figure S1E), which was confirmed by the decreased number of Sirt1 positive ARC nuclei (Figure S1F, G).
Gene_expression (expression) of Sirt1 associated with aids-related complex
16) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.55 Pain Relevance 0
Western blotting from remote area confirmed the result from our earlier studies [15], that Sirt1 protein was overexpressed in GK rats.
Gene_expression (overexpressed) of Sirt1 protein
17) Confidence 0.73 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.72 Pain Relevance 0
Our study showed that Sirt1 protein was overexpressed in both the remote area (posterior wall) and in the infarct area (anterior wall).
Gene_expression (overexpressed) of Sirt1 protein in posterior
18) Confidence 0.73 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.63 Pain Relevance 0
Western blotting showed an increase in Sirt1 protein expression in sham-operated GK rats compared to Wistar with no further increase in Sirt1 protein expression after MI (Figure 6A).
Gene_expression (expression) of Sirt1 protein associated with myocardial infarction
19) Confidence 0.73 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.40 Pain Relevance 0
Sirt1 protein overexpression was further associated with a decrease in p53 acetylation in GK rats postligation.
Gene_expression (overexpression) of Sirt1 protein
20) Confidence 0.73 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.59 Pain Relevance 0.17

General Comments

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