INT28958

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.49
Pain Relevance 0.65

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signal transduction (Wnt7a) extracellular space (Wnt7a) extracellular region (Wnt7a)
proteinaceous extracellular matrix (Wnt7a) plasma membrane (Wnt7a) cell-cell signaling (Wnt7a)
Wnt7a (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 96.24 Very High Very High Very High
Nicotine 1 30.72 Quite Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 8 95.94 Very High Very High Very High
Stress 15 93.60 High High
Disease 5 42.32 Quite Low
Nicotine Addiction 5 18.76 Low Low
Cancer 2 16.12 Low Low
Genetic Predisposition To Disease 1 7.04 Low Low
Exsanguination 1 5.00 Very Low Very Low Very Low
Burns 1 5.00 Very Low Very Low Very Low
Pulmonary Disease 1 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of inhibitors of these enzymes on the toxicity of paracetamol and on t-butylhydroperoxide (t-BOOH), used as a positive control, was determined. 1,3-Bis(chloroethyl)-1-nitrosourea (BCNU) was used to inhibit GSSG-Rd, and goldthioglucose (GTG) used to inhibit GSH-Px.
Negative_regulation (inhibit) of GSH-Px associated with toxicity and paracetamol
1) Confidence 0.45 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2818629 Disease Relevance 0.49 Pain Relevance 0.48
Furthermore, it has been determined that cytosolic glutathione S-transferase (GST) activity was decreased and glutathione peroxidase (GSH-Px) activity remained unchanged.
Negative_regulation (decreased) of GSH-Px
2) Confidence 0.23 Published 1994 Journal J Appl Toxicol Section Abstract Doc Link 7963244 Disease Relevance 0 Pain Relevance 0.17
AT supplementation enhanced GR and catalase activities as compared to their controls, whereas a decline in GSH-Px from 10.50 ± 0.27 to 7.46 ± 0.52 nmole NADPH consumed min-1mg protein-1 was observed in this group.
Negative_regulation (decline) of GSH-Px
3) Confidence 0.06 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0 Pain Relevance 0

General Comments

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