INT289584

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.35
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
nucleolus (Sirt1) nucleus (Sirt1) enzyme binding (Sirt1)
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 10 59.88 Quite High
Inflammation 3 14.40 Low Low
fibrosis 14 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 78 97.92 Very High Very High Very High
Apoptosis 42 89.76 High High
Aids-related Complex 44 88.24 High High
Stress 10 87.44 High High
Hypertrophy 14 84.64 Quite High
Targeted Disruption 18 72.24 Quite High
Body Weight 34 66.16 Quite High
Diabetes Mellitus 55 50.00 Quite Low
Weight Gain 8 47.04 Quite Low
Coronary Heart Disease 10 27.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transcription factors Stat3 and FoxO1 (Figure S4A) are involved in the regulation of POMC gene expression, and both were shown to functionally interact with Sirt1 [28], [29].
Sirt1 Binding (interact) of
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.21 Pain Relevance 0
Deacetylation of FoxO1 by Sirt1 was shown to stimulate its DNA binding, and transcriptional activity [2], [29], [36].
Sirt1 Binding (binding) of
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.23 Pain Relevance 0.03
Furthermore we showed that increased Sirt1 protein in the remote area was associated with deacetylation of the Sirt1-target p53 in GK + MI rats.
Sirt1 protein Binding (associated) of associated with myocardial infarction
3) Confidence 0.35 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.91 Pain Relevance 0

General Comments

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