INT289587

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.65
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1) nuclear envelope (Sirt1) histone binding (Sirt1)
nucleolus (Sirt1) nucleus (Sirt1) enzyme binding (Sirt1)
Anatomy Link Frequency
body 2
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 10 97.72 Very High Very High Very High
anesthesia 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 34 100.00 Very High Very High Very High
Aids-related Complex 44 86.32 High High
Weight Gain 8 84.88 Quite High
Hyperphagia 2 64.40 Quite High
Targeted Disruption 18 35.12 Quite Low
Obesity 10 5.00 Very Low Very Low Very Low
Appetite Loss 10 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Metabolic Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fasting induced decrease in p53 acetylation [10] was also reversed by inhibition of Sirt1 function, and Stat3 acetylation was insensitive to Sirt1 inhibition (data not shown).
Negative_regulation (insensitive) of Negative_regulation (inhibition) of Sirt1
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.16 Pain Relevance 0
Blocking the melanocortin receptors consistently abolished the decreased food intake and body weight gain in hypothalamic Sirt1 inhibited animals, showing that melanocortin receptors mediate the effect of Sirt1 on energy balance.
Negative_regulation (Blocking) of Negative_regulation (abolished) of Sirt1 in body associated with body weight
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.49 Pain Relevance 0.05

General Comments

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