INT28959

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Context Info
Confidence 0.20
First Reported 1986
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.52
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Rdbp) RNA binding (Rdbp) nucleus (Rdbp)
Anatomy Link Frequency
neuron 2
hepatocytes 1
Rdbp (Mus musculus)
Pain Link Frequency Relevance Heat
Raphe 22 100.00 Very High Very High Very High
depression 2 100.00 Very High Very High Very High
fluoxetine 2 99.62 Very High Very High Very High
5HT 2 99.04 Very High Very High Very High
Serotonin 18 98.44 Very High Very High Very High
Paracetamol 29 97.48 Very High Very High Very High
monoamine 2 89.92 High High
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Toxicity 18 96.96 Very High Very High Very High
Stress 5 89.60 High High
Injury 2 41.76 Quite Low
Poisoning 1 34.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, after inhibition of GSSG-Rd with BCNU, hepatocytes from these postnatal mice were more susceptible to paracetamol toxicity.
Negative_regulation (inhibition) of GSSG-Rd in hepatocytes associated with toxicity and paracetamol
1) Confidence 0.20 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2818629 Disease Relevance 0.63 Pain Relevance 0.71
The effect of inhibitors of these enzymes on the toxicity of paracetamol and on t-butylhydroperoxide (t-BOOH), used as a positive control, was determined. 1,3-Bis(chloroethyl)-1-nitrosourea (BCNU) was used to inhibit GSSG-Rd, and goldthioglucose (GTG) used to inhibit GSH-Px.
Negative_regulation (inhibit) of GSSG-Rd associated with toxicity and paracetamol
2) Confidence 0.20 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2818629 Disease Relevance 0.49 Pain Relevance 0.48
Pretreatment with 1,3-bis(chloroethyl)-1-nitrosourea (BCNU) (0.1 mM) for 30 min, which irreversibly inhibited glutathione reductase (GSSG-Rd) activity, increased the extent of GSSG formation produced by APAP exposure and potentiated its cell killing.
Negative_regulation (inhibited) of GSSG-Rd associated with paracetamol
3) Confidence 0.05 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8517869 Disease Relevance 0.22 Pain Relevance 0.77
The 5HT reuptake blocker, fluoxetine, produced a total suppression of RD neuron activity in vitro.
Negative_regulation (suppression) of RD neuron in neuron associated with 5ht, raphe and fluoxetine
4) Confidence 0.02 Published 1986 Journal Exp Brain Res Section Abstract Doc Link 2941313 Disease Relevance 0.09 Pain Relevance 0.87
Similarly, increasing the concentration of serotonin in the tissue slice by adding serotonin directly to the incubation medium resulted in a profound, though transitory, depression of RD neuron activity.
Negative_regulation (depression) of RD neuron in neuron associated with depression, raphe and serotonin
5) Confidence 0.02 Published 1986 Journal Exp Brain Res Section Abstract Doc Link 2941313 Disease Relevance 0.10 Pain Relevance 1.00

General Comments

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