INT289599

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Context Info
Confidence 0.51
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sirt1, Ppargc1a) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) mitochondrion organization (Ppargc1a) DNA binding (Ppargc1a)
Anatomy Link Frequency
liver 1
Sirt1 (Rattus norvegicus)
Ppargc1a (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 1 59.60 Quite High
Hippocampus 1 44.08 Quite Low
antagonist 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 5 93.60 High High
Metabolic Disorder 2 92.64 High High
Repression 1 82.48 Quite High
Disease 1 34.88 Quite Low
Aging 2 17.60 Low Low
Aids-related Complex 22 5.00 Very Low Very Low Very Low
Body Weight 17 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Appetite Loss 5 5.00 Very Low Very Low Very Low
Weight Gain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the liver, Sirt1 deacetylates and activates the transcriptional co-activator PGC1-alpha and the transcription factor FoxO1 to promote gluconeogenesis [2], [3].
Sirt1 Positive_regulation (activates) of PGC1-alpha in liver
1) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

This test has worked.

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