INT289600

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1, Sirt1) nuclear envelope (Sirt1, Sirt1) histone binding (Sirt1, Sirt1)
enzyme binding (Sirt1, Sirt1) cytoplasm (Sirt1, Sirt1) nucleolus (Sirt1, Sirt1)
Sirt1 (Mus musculus)
Sirt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 10 36.80 Quite Low
addiction 2 18.88 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 34 94.64 High High
Aids-related Complex 44 79.92 Quite High
Body Weight Changes 2 76.24 Quite High
Obesity 10 59.08 Quite High
Weight Gain 8 57.84 Quite High
Appetite Loss 10 38.12 Quite Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Metabolic Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This compound (EX-527) is a small, selective inhibitor of SIRT1 that does not inhibit histone deacetylases and is specific for Sirt1 over other sirtuin family members [16], [17].
Negative_regulation (inhibitor) of sirtuin Binding (specific) of Sirt1
1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.58 Pain Relevance 0
This compound (EX-527) is a small, selective inhibitor of SIRT1 that does not inhibit histone deacetylases and is specific for Sirt1 over other sirtuin family members [16], [17].
Negative_regulation (inhibitor) of sirtuin Binding (specific) of SIRT1
2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.58 Pain Relevance 0

General Comments

This test has worked.

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