INT289602

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1, PPARG) enzyme binding (Sirt1, PPARG) cytoplasm (Sirt1, PPARG)
nucleus (Sirt1, PPARG) nuclear envelope (Sirt1) histone binding (Sirt1)
Anatomy Link Frequency
pancreas 1
Sirt1 (Rattus norvegicus)
PPARG (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 1 74.32 Quite High
Hippocampus 1 58.80 Quite High
antagonist 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 5 99.96 Very High Very High Very High
Repression 1 98.60 Very High Very High Very High
Metabolic Disorder 2 85.76 High High
Disease 1 49.60 Quite Low
Aging 2 32.32 Quite Low
Aids-related Complex 22 5.00 Very Low Very Low Very Low
Body Weight 17 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Appetite Loss 5 5.00 Very Low Very Low Very Low
Weight Gain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the adipose tissue, Sirt1 triggers fat mobilization by inhibiting peroxisome proliferator-activated receptor (PPAR-gamma), and in the pancreas repression of the uncoupling protein 2 (UCP2) by Sirt1 increases insulin secretion [1].
Sirt1 Negative_regulation (inhibiting) of peroxisome proliferator-activated receptor in pancreas associated with repression and obesity
1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.37 Pain Relevance 0.07

General Comments

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