INT289617

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Context Info
Confidence 0.75
First Reported 2009
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 10
Disease Relevance 0.84
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SMYD1) DNA binding (SMYD1) cytoplasm (SMYD1)
Anatomy Link Frequency
brain 2
heart 2
cardiomyocytes 1
developmental stages 1
SMYD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 1 35.36 Quite Low
fibrosis 9 35.28 Quite Low
imagery 54 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 3 99.28 Very High Very High Very High
Dermatological Disease 1 90.44 High High
Embryonic Lethality 18 78.16 Quite High
Body Weight 9 78.08 Quite High
Congenital Anomalies 9 71.28 Quite High
Targeted Disruption 63 60.72 Quite High
Necrosis 18 42.00 Quite Low
Injury 1 39.08 Quite Low
Infection 1 38.68 Quite Low
Cardiovascular Disorder Under Development 9 35.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SMYD5 is a member of the SMYD family and its expression also responds to RA induction [19].
Gene_expression (expression) of SMYD associated with rheumatoid arthritis
1) Confidence 0.75 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.28 Pain Relevance 0
Since the loss of Smyd2 functional activity might result in compensation by other Smyd-family members, we also investigated whether expression levels of the related Smyd genes 1–5 are affected by Smyd2 deletion.
Spec (whether) Gene_expression (expression) of Smyd
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.13 Pain Relevance 0
No significant changes were detected for other Smyd transcripts (Fig. 4E).


Gene_expression (transcripts) of Smyd
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.13 Pain Relevance 0
Temporal expression profiling of Smyd-family members during cardiac development
Gene_expression (expression) of Smyd
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0 Pain Relevance 0
Since we have recently identified Smyd2 as a distinct Smyd -family member that is most highly expressed in heart and brain [20], we performed a study aimed at expanding the understanding of Smyd proteins in the heart with specific focus on Smyd2.
Gene_expression (expressed) of Smyd in heart
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.07 Pain Relevance 0
Taken together, the data indicate that Smyd1 and Smyd2 are the only Smyd-family members observed to be preferentially expressed in cardiomyocytes, and their levels are markedly regulated during cardiac development.


Gene_expression (expressed) of Smyd in cardiomyocytes
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0 Pain Relevance 0
To determine the temporal expression patterns of Smyd-family members during vertebrate heart development, we collected mouse cardiac ventricles at sequential developmental stages from embryonic (E) days 12.5 to 18.5, postnatal (P) days 1 to 7 and adult and determined the relative mRNA expression levels of Smyd1-5.
Spec (determine) Gene_expression (expression) of Smyd in developmental stages
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0 Pain Relevance 0
Since we have recently identified Smyd2 as a distinct Smyd -family member that is most highly expressed in heart and brain [20], we performed a study aimed at expanding the understanding of Smyd proteins in the heart with specific focus on Smyd2.
Gene_expression (expressed) of Smyd in heart
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.08 Pain Relevance 0
Since we have recently identified Smyd2 as a distinct Smyd -family member that is most highly expressed in heart and brain [20], we performed a study aimed at expanding the understanding of Smyd proteins in the heart with specific focus on Smyd2.
Gene_expression (expressed) of Smyd in brain
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.07 Pain Relevance 0
Since we have recently identified Smyd2 as a distinct Smyd -family member that is most highly expressed in heart and brain [20], we performed a study aimed at expanding the understanding of Smyd proteins in the heart with specific focus on Smyd2.
Gene_expression (expressed) of Smyd in brain
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.08 Pain Relevance 0

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