INT289630

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.10
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CDSN, RS1) cell adhesion (CDSN, RS1) extracellular space (RS1)
CDSN (Homo sapiens)
RS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 25 97.22 Very High Very High Very High
psoriasis 3 96.68 Very High Very High Very High
Multiple sclerosis 48 54.24 Quite High
rheumatoid arthritis 50 47.56 Quite Low
Crohn's disease 13 22.48 Low Low
Inflammation 5 17.44 Low Low
Arthritis 7 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Infliximab 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 147 98.38 Very High Very High Very High
Diabetes Mellitus 34 97.96 Very High Very High Very High
Low Back Pain 25 97.22 Very High Very High Very High
Psoriasis 3 96.68 Very High Very High Very High
Autoimmune Disease 53 84.08 Quite High
Thyroid Disease 34 54.92 Quite High
Demyelinating Disease 50 54.24 Quite High
Rheumatoid Arthritis 57 47.56 Quite Low
Breast Cancer 6 32.28 Quite Low
Coronary Artery Disease 6 32.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While mutations in this gene have been previously associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and Grave’s Disease [28]–[30], the inverse allelic relationship has not been previously recognized. rs1265048 falls near CDSN and PSORS1C1 both of which have previously been associated with susceptibility to psoriasis [31],[32]. rs151719 falls in HLA-DMB, an MHC class II molecule that has been previously associated with T1D [33].
CDSN Binding (falls) of rs1265048 associated with psoriasis, spinal inflammation, diabetes mellitus and disease
1) Confidence 0.02 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2791168 Disease Relevance 1.10 Pain Relevance 0.17

General Comments

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