INT289649

Context Info Confidence 0.21 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.66 Pain Relevance 0.72

plasma membrane (Flt4) nucleus (Flt4) kinase activity (Flt4) cytoplasm (Flt4)

Flt4 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 31 100.00 cytokine 11 100.00 cINOD 30 99.76 chemokine 4 31.28 Inflammatory mediators 3 5.00 Inflammatory response 2 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 37 100.00 Lymphedema 45 90.96 Increased Venous Pressure Under Development 3 50.00 Pressure And Volume Under Development 10 31.24 Disease 5 5.00 Cancer 3 5.00 Necrosis 2 5.00 Injury 2 5.00 Metastasis 1 5.00 Inflammatory Bowel Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The NSAID-induced up-regulation of these pro-inflammatory cytokines was accompanied by significant, parallel up-regulation of VEGF-C, VEGFR-3, and Prox1 expression.

Regulation (regulation) of Gene_expression (expression) of VEGFR-3 associated with inflammation, cinod and cytokine

1) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 0.66 Pain Relevance 0.72

General Comments

This test has worked.