INT289670

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Context Info
Confidence 0.34
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NPVF, GNRH1) signal transduction (GNRH1) extracellular space (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
pituitary 2
NPVF (Homo sapiens)
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 88.28 High High
Pain 2 61.20 Quite High
Neuropeptide 6 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
endometriosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 61.20 Quite High
Stress 2 20.24 Low Low
Appetite Loss 2 19.60 Low Low
Diabetes Mellitus 2 18.80 Low Low
Obesity 2 18.00 Low Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Precocious Puberty 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, human RFRP-3, which is identical in sequence to sheep RFRP-3, potently inhibits gonadotropin secretion in vivo in sheep and GnRH stimulation of gonadotropin secretion from cultured sheep pituitary cells [26], [27].
RFRP Negative_regulation (inhibits) of Positive_regulation (stimulation) of GnRH in pituitary
1) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791420 Disease Relevance 0.06 Pain Relevance 0.06
The human RFRP-3 was recently shown to potently inhibit GnRH stimulation of gonadotropin secretion from sheep in vivo and from cultured gonadotropes through inhibition of Ca2+ mobilization [26].
RFRP Negative_regulation (inhibit) of Positive_regulation (stimulation) of GnRH
2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791420 Disease Relevance 0 Pain Relevance 0.04

General Comments

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