INT2897

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Context Info
Confidence 0.45
First Reported 1975
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 5.17
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Thra) mitochondrion (Thra) nucleus (Thra)
DNA binding (Thra) nucleic acid binding transcription factor activity (Thra) transcription factor binding (Thra)
Anatomy Link Frequency
blood 4
SVR 1
RAO 1
kidney 1
Thra (Mus musculus)
Pain Link Frequency Relevance Heat
cva 9 100.00 Very High Very High Very High
antagonist 5 99.72 Very High Very High Very High
anesthesia 17 99.60 Very High Very High Very High
isoflurane 8 95.04 Very High Very High Very High
lidocaine 5 91.36 High High
Morphine 2 89.08 High High
Rostral ventromedial medulla 1 84.52 Quite High
Mexiletine 3 84.08 Quite High
Rostral ventrolateral medulla 1 81.28 Quite High
medulla 2 80.04 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 30 100.00 Very High Very High Very High
Cv General 3 Under Development 9 100.00 Very High Very High Very High
Stress 3 99.46 Very High Very High Very High
Diabetes Mellitus 8 97.88 Very High Very High Very High
Premature Ventricular Beats 6 94.68 High High
Acute Renal Failure 2 83.24 Quite High
Hepatitis C Virus Infection 104 80.80 Quite High
Increased Venous Pressure Under Development 3 76.64 Quite High
Ureteral Obstruction 4 75.00 Quite High
Nephrotoxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 13 of the 21 patients, repetitive ventricular response (RVR) was successfully induced.
Positive_regulation (induced) of RVR
1) Confidence 0.45 Published 1983 Journal Jpn. Circ. J. Section Abstract Doc Link 6827769 Disease Relevance 0.84 Pain Relevance 0.12
Selective stimulation with microelectrodes increased RVR, MVR, and HQVR, with RVMM producing the strongest response in HQVR and RVLM the strongest effect on RVR.
Positive_regulation (increased) of RVR
2) Confidence 0.42 Published 1988 Journal Clin Exp Hypertens A Section Abstract Doc Link 3242985 Disease Relevance 0 Pain Relevance 0.34
Amrinone induced no significant changes in IVR or RVR during basal chloralose anesthesia.
Neg (no) Positive_regulation (induced) of RVR associated with anesthesia
3) Confidence 0.39 Published 1991 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2038924 Disease Relevance 0.08 Pain Relevance 0.42
In general, the patient characteristics that were more likely to be associated with achievement of RVR and cEVR were similar.


Positive_regulation (achievement) of RVR
4) Confidence 0.33 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.66 Pain Relevance 0.24
There is evidence of increased oxidative stress that is implicated in the increase in the BP and RVR in this model.
Positive_regulation (increase) of RVR associated with stress
5) Confidence 0.31 Published 2002 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 12444204 Disease Relevance 0.17 Pain Relevance 0
Since ribavirin dose is one of the only modifiable factors identified in this analysis that is associated with an increase in RVR and cEVR, physicians may be advised to maintain a higher ribavirin dose to increase the likelihood of achieving SVR.
Positive_regulation (increase) of RVR in SVR
6) Confidence 0.31 Published 2010 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2810441 Disease Relevance 0.34 Pain Relevance 0
However, an increase in resting tonus on the cervical side resulted in an increase in maternal blood pressure, slight increases in R-SNA and RVR, and an increase in RBF.
Positive_regulation (increases) of RVR in blood
7) Confidence 0.25 Published 1989 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 2768961 Disease Relevance 0 Pain Relevance 0.08
A secondary RVR increase began at 7-9 s and reached maximum speed at 10-15 s.
Positive_regulation (increase) of RVR
8) Confidence 0.22 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12791588 Disease Relevance 0 Pain Relevance 0
An increase in resting tonus on the ovarian side caused an increase in maternal blood pressure, increases in R-SNA and renal vascular resistance (RVR), and a decrease in RBF.
Positive_regulation (increases) of RVR in blood
9) Confidence 0.22 Published 1989 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 2768961 Disease Relevance 0 Pain Relevance 0.09
Indomethacin induced significant (p less than 0.05) increases in renal vascular resistance (RVR) which were attenuated by either concurrent treatment with captopril or infusion of PGE1 at the time of study.
Positive_regulation (increases) of RVR
10) Confidence 0.17 Published 1989 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2648648 Disease Relevance 0.07 Pain Relevance 0.07
These experiments indicate that during RAO release of renin causes, through formation of angiotensin, an increase in RVR in the contralateral kidney and intra-arterial administration of P-113 restores the vascular resistance to a near-normal level.
Positive_regulation (increase) of RVR in RAO
11) Confidence 0.13 Published 1975 Journal Am. J. Physiol. Section Abstract Doc Link 1211457 Disease Relevance 0 Pain Relevance 0.07
An increase in renin secretion rate was obtained in the ischemic kidney, which was accompanied by an increase in renal vascular resistance (RVR) in the contralateral kidney and a rise in systemic blood pressure.
Positive_regulation (increase) of RVR in blood
12) Confidence 0.11 Published 1975 Journal Am. J. Physiol. Section Abstract Doc Link 1211457 Disease Relevance 0 Pain Relevance 0.09
Following indomethacin a sustained increase in ipsilateral renal vascular resistance (RVR) was observed from 37.6 +/- 3.6 mm.
Positive_regulation (increase) of RVR
13) Confidence 0.10 Published 1993 Journal J. Urol. Section Abstract Doc Link 8411451 Disease Relevance 0.20 Pain Relevance 0.07
Increasing ICP 10 torr during enflurane-N-2O anesthesia caused significant increases (compared to enflurane-N2O values in the presence of normal ICP) in UosM, RVR, and CosM, as well as significant decreases in UVOL, CH2O, AND CPAH, but had no effect on ADH, CIN, or MAP.
Positive_regulation (increases) of RVR associated with anesthesia and cva
14) Confidence 0.07 Published 1978 Journal Anesth. Analg. Section Abstract Doc Link 565158 Disease Relevance 0.55 Pain Relevance 0.68
RAO induced an increase in arterial plasma renin activity and this increase was accompanied by an increase in RVR in the contralateral kidney and rise in SBP.
Positive_regulation (increase) of RVR in kidney
15) Confidence 0.06 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7009942 Disease Relevance 0 Pain Relevance 0
EP properties: DP significantly extended QTc, ERPRV, and the coupling interval by which VT or repetitive ventricular response (RVR) was induced.
Positive_regulation (induced) of RVR associated with heart rate under development
16) Confidence 0.04 Published 1988 Journal Jpn. Circ. J. Section Abstract Doc Link 3373720 Disease Relevance 0.77 Pain Relevance 0.16
Although no significant extension of QRS width was found, the significant extension of the interval from extrastimulus to the first induced VT or RVR complex by the three drugs indicates that all have suppressive effects on conduction velocity within the reentry circuit.
Positive_regulation (induced) of RVR associated with heart rate under development
17) Confidence 0.04 Published 1988 Journal Jpn. Circ. J. Section Abstract Doc Link 3373720 Disease Relevance 0.79 Pain Relevance 0.15
Renal vascular resistance (RVR) was high before surgery and further increased after sternotomy (from 18,086 +/- 6849 to 30,070 +/- 24,427 dynes.s.cm-5), decreasing during CPB to 13,9647 +/- 14,662 dynes.s.cm-5.
Positive_regulation (increased) of RVR
18) Confidence 0.04 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7653802 Disease Relevance 0 Pain Relevance 0.06
Y-24180 (0.3 and 3 mg/kg) significantly prevented the reductions in PAH clearance and the increase in calculated renal vascular resistance (RVR) in a dose-dependent manner.
Positive_regulation (increase) of RVR
19) Confidence 0.03 Published 2001 Journal Life Sci. Section Abstract Doc Link 11228102 Disease Relevance 0.22 Pain Relevance 0.20
In two-week-old diabetic rats, a specific TXA2 synthetase inhibitor, OKY-046, or a specific TXA2 receptor antagonist, Sulotroban, increased renal vascular resistance (RVR) and ameliorated the hyperperfusion.
Positive_regulation (increased) of RVR associated with diabetes mellitus and antagonist
20) Confidence 0.02 Published 1994 Journal Kidney Int. Section Abstract Doc Link 8196281 Disease Relevance 0.43 Pain Relevance 0.18

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