INT28970

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 1.65
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Chgb)
Anatomy Link Frequency
adrenal medulla 1
Chgb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 13 100.00 Very High Very High Very High
Dopamine 9 100.00 Very High Very High Very High
Catecholamine 4 99.64 Very High Very High Very High
medulla 6 99.20 Very High Very High Very High
corticosteroid 2 97.64 Very High Very High Very High
narcan 5 95.56 Very High Very High Very High
Analgesic 4 92.40 High High
opioid receptor 2 90.72 High High
Somatostatin 2 75.08 Quite High
Neuropeptide 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Arterial-venous Cerebral Malformations 40 100.00 Very High Very High Very High
Cancer 6 99.40 Very High Very High Very High
Nociception 4 97.48 Very High Very High Very High
Carcinoma 4 91.24 High High
Catalepsy 1 79.76 Quite High
Prostate Cancer 2 75.00 Quite High
Adenocarcinoma 4 60.80 Quite High
Arthritis 5 19.56 Low Low
Pressure And Volume Under Development 16 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We can conclude that nervous stimulation of the adrenal medulla (by insulin and reserpine) induces the synthesis of enkephalins, dopamine beta-hydroxylase, the amine carrier and chromogranin B whereas the level of chromogranin A apparently depends on corticosteroids.
Gene_expression (synthesis) of chromogranin B in adrenal medulla associated with medulla, corticosteroid, dopamine and enkephalin
1) Confidence 0.75 Published 1987 Journal Neuroscience Section Abstract Doc Link 2819772 Disease Relevance 0 Pain Relevance 0.76
Insulin treatment induced increased levels of enkephalins, dopamine beta-hydroxylase, the amine carrier and of chromogranin B whereas catecholamines, cytochrome b-561 and chromagranin A remained slightly below control levels.
Gene_expression (levels) of chromogranin B associated with dopamine, catecholamine and enkephalin
2) Confidence 0.65 Published 1987 Journal Neuroscience Section Abstract Doc Link 2819772 Disease Relevance 0 Pain Relevance 0.67
g of pCMV–POMC followed by injection with CFA; SG VII (n = 7), intramuscular electroporation with PBS followed by injection with CFA; SG VIII (n = 7), intramuscular PBS injection with CFA only (this group was used to determine whether CFA itself significantly induced the production of endogenous ACTH and endorphin); SG IX (n = 7), treated as SG VI except that, 30 minutes before the nociceptive test at 7 days after CFA injection, naloxone (1 mg/kg) was administered intraperitoneally to determine whether any analgesic effect was mediated through the opioid receptors; and SG X (n = 7), intramuscular electroporation with 200 ?
Spec (determine) Gene_expression (determine) of SG I associated with nociception, analgesic, narcan and opioid receptor
3) Confidence 0.65 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400409 Disease Relevance 0.10 Pain Relevance 0.19
However, there was a significant increase in serum levels of CgB during the same period, P = 0.002, possibly due to an increase in number of NE cells in tumor or to a relative increase in production of CgB in the NE cells.
Gene_expression (production) of CgB associated with cancer
4) Confidence 0.36 Published 1997 Journal Prostate Section Abstract Doc Link 9140124 Disease Relevance 0.47 Pain Relevance 0.13
However, there was a significant increase in serum levels of CgB during the same period, P = 0.002, possibly due to an increase in number of NE cells in tumor or to a relative increase in production of CgB in the NE cells.
Gene_expression (levels) of CgB associated with cancer
5) Confidence 0.28 Published 1997 Journal Prostate Section Abstract Doc Link 9140124 Disease Relevance 0.54 Pain Relevance 0.14
There are, however, differences between the projections originating from these cortical fields; the density of terminals in the SC was larger and the pattern of terminals in the ipsilateral SGI was more patchy after injections in the AVF, whereas the SGI projection appears to be more targeted when the tracer was placed in the PSF (Figure 4).
Gene_expression (projection) of SGI associated with arterial-venous cerebral malformations
6) Confidence 0.05 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2904598 Disease Relevance 0.23 Pain Relevance 0
There are, however, differences between the projections originating from these cortical fields; the density of terminals in the SC was larger and the pattern of terminals in the ipsilateral SGI was more patchy after injections in the AVF, whereas the SGI projection appears to be more targeted when the tracer was placed in the PSF (Figure 4).
Gene_expression (projection) of SGI associated with arterial-venous cerebral malformations
7) Confidence 0.05 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2904598 Disease Relevance 0.23 Pain Relevance 0
Gene expression of enkephalin, chromogranin A, chromogranin B, and secretogranin II and their respective peptide products were studied with in situ hybridization and radioimmunoassays after daily oral administration of haloperidol, clozapine, risperidone, or zotepine for 21 days.
Gene_expression (expression) of chromogranin B associated with enkephalin
8) Confidence 0.05 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10869885 Disease Relevance 0.08 Pain Relevance 0.26

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