INT289704

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.42
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
cleavage 1
spleen 1
stem cell 1
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 32 90.36 High High
Inflammation 4 89.28 High High
corticosteroid 2 78.00 Quite High
cINOD 2 73.20 Quite High
ischemia 16 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 120 96.44 Very High Very High Very High
Targeted Disruption 90 94.12 High High
Adhesions 30 93.52 High High
Apoptosis 8 91.36 High High
Blister 72 89.32 High High
INFLAMMATION 6 89.28 High High
Death 4 86.08 High High
Cancer 4 81.08 Quite High
Coagulation Disorder 16 69.16 Quite High
Disease 16 12.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While PAR signaling pathways might control stem/progenitor cells directly, another major pathway could potentially be mediated non-autonomously by stromal cells in the stem cell niche, through the cleavage of osteopontin (Spp1, OPN) by thrombin.
Protein_catabolism (cleavage) of osteopontin in stem cell
1) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.39 Pain Relevance 0.09
Our present finding that treatment of factor VIII KO recipients of pig embryonic spleen exhibit a deuced implant size, similarly to that found in the non-hemophilic recipients, strongly indicates that thrombin likely exerts its regulatory effect through cleavage of OPN .
Protein_catabolism (cleavage) of OPN in cleavage
2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.19 Pain Relevance 0.03
In contrast, treatment of Factor VIII KO recipients of pig spleen implants with trOPN exhibited a significant inhibition of implant size comparable to that found in the non-hemophlic recipients, suggesting that the regulatory role of thrombin is mediated through trOPN, cleaved by thrombin from OPN.


Protein_catabolism (cleaved) of trOPN in spleen
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.09 Pain Relevance 0.08
Thrombin is the major serine protease that cleaves OPN, giving rise to a 24-kDa and a 45-kDa fragment.
Protein_catabolism (cleaves) of OPN
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.30 Pain Relevance 0.07
What remains to be addressed in future studies is (1) whether ectopic expression of Dsg2 alters the sensitivity of Dsg1 to degradation by ETA or loss of function upon antibody binding, and (2) whether the loss of Dsg1 function in pemphigus is caused by altered signaling and/or steric hindrance.
Protein_catabolism (degradation) of ETA associated with bullous skin disease
5) Confidence 0.22 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.76 Pain Relevance 0.11
Western blotting showed that ETA cleaves Dsg1, resulting in a smaller fragment approximately 113?
Protein_catabolism (cleaves) of ETA
6) Confidence 0.16 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.69 Pain Relevance 0

General Comments

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