INT28971

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Context Info
Confidence 0.47
First Reported 1987
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.58
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
adrenal medulla 2
SCG 2
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 17 100.00 Very High Very High Very High
Dopamine 13 100.00 Very High Very High Very High
medulla 11 100.00 Very High Very High Very High
Catecholamine 7 98.00 Very High Very High Very High
corticosteroid 3 96.12 Very High Very High Very High
Neuropeptide 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Stress 8 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin treatment induced increased levels of enkephalins, dopamine beta-hydroxylase, the amine carrier and of chromogranin B whereas catecholamines, cytochrome b-561 and chromagranin A remained slightly below control levels.
Positive_regulation (induced) of Gene_expression (levels) of dopamine beta-hydroxylase associated with dopamine, catecholamine and enkephalin
1) Confidence 0.47 Published 1987 Journal Neuroscience Section Abstract Doc Link 2819772 Disease Relevance 0 Pain Relevance 0.66
We can conclude that nervous stimulation of the adrenal medulla (by insulin and reserpine) induces the synthesis of enkephalins, dopamine beta-hydroxylase, the amine carrier and chromogranin B whereas the level of chromogranin A apparently depends on corticosteroids.
Positive_regulation (induces) of Gene_expression (synthesis) of dopamine beta-hydroxylase in adrenal medulla associated with medulla, corticosteroid, dopamine and enkephalin
2) Confidence 0.47 Published 1987 Journal Neuroscience Section Abstract Doc Link 2819772 Disease Relevance 0 Pain Relevance 0.77
Insulin treatment induced increased levels of enkephalins, dopamine beta-hydroxylase, the amine carrier and of chromogranin B whereas catecholamines, cytochrome b-561 and chromagranin A remained slightly below control levels.
Positive_regulation (increased) of Gene_expression (levels) of dopamine beta-hydroxylase associated with dopamine, catecholamine and enkephalin
3) Confidence 0.47 Published 1987 Journal Neuroscience Section Abstract Doc Link 2819772 Disease Relevance 0 Pain Relevance 0.66
In contrast, TH and DBH mRNA levels in the SCG, but not in adrenal medulla, were elevated by ACTH administration, similar to the levels attained after immobilization.
Positive_regulation (elevated) of Gene_expression (levels) of DBH mRNA in SCG associated with medulla
4) Confidence 0.46 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.58 Pain Relevance 0.31

General Comments

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