INT289711

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.21
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F2, Spp1) extracellular region (F2, Spp1) peptidase activity (F2)
cell adhesion (Spp1) cytoplasm (Spp1)
Anatomy Link Frequency
stroma 1
F2 (Mus musculus)
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 24 92.08 High High
ischemia 12 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 12 73.76 Quite High
Severe Combined Immunodeficiency 111 71.12 Quite High
Death 3 34.32 Quite Low
Apoptosis 6 21.88 Low Low
Cv Unclassified Under Development 12 5.00 Very Low Very Low Very Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, our ability to reverse the enhancement of implant size by treatment with the cleaved form of OPN that is released upon treatment with thrombin, strongly indicates that thrombin likely exerts its regulatory activity through interaction with OPN on stroma cells, as previously shown for maintenance of the blood tissue size under normal steady state hoemostasis[9], [10].


thrombin Binding (interaction) of OPN in stroma
1) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.21 Pain Relevance 0
Thrombin can also affect cells indirectly by cleaving OPN which is a secreted, multifunctional glycoprotein that exists either as a full-length molecule or as proteolytically cleaved fragments.
Thrombin Binding (cleaving) of OPN
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0 Pain Relevance 0
Thus, it was of interest to define whether thrombin enhances implant size through PAR signaling or via its effect on OPN.
thrombin Binding (effect) of OPN
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0 Pain Relevance 0.08

General Comments

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