INT289725

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 1.84
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Sat1) transferase activity, transferring acyl groups (Sat1) cytoplasm (Sat1)
Anatomy Link Frequency
hair 2
Sat1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 110 96.92 Very High Very High Very High
fibrosis 10 66.28 Quite High
Dismenorea 10 6.56 Low Low
endometriosis 10 5.36 Low Low
Kinase C 110 5.00 Very Low Very Low Very Low
adenocard 20 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 30 99.98 Very High Very High Very High
Alopecia 10 98.20 Very High Very High Very High
Female Infertility 10 97.76 Very High Very High Very High
Pancreatitis 10 94.72 High High
Intestinal Cancer 20 79.36 Quite High
Cancer 10 68.16 Quite High
Fibrosis 10 66.28 Quite High
Reprotox - General 1 20 6.56 Low Low
Endometriosis (extended) 60 5.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No significant elevation of SAT1 gene expression was observed following PGF treatment alone.
Neg (No) Positive_regulation (elevation) of Gene_expression (expression) of SAT1 gene
1) Confidence 0.49 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.04
q cross-talk via AC3, such that siRNA knockdown of the AC3 isoform completely inhibited the potentiation of Butaprost-stimulated SAT1 expression by PGF.
Positive_regulation (stimulated) of Gene_expression (expression) of SAT1
2) Confidence 0.36 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.69 Pain Relevance 0.03
To determine whether the PGF-mediated potentiation of SAT1 expression is mediated by the FP receptor, the cells were treated with the FP receptor antagonist (AL8810) in the presence/absence of Butaprost and/or PGF for 6 h.
Spec (whether) Positive_regulation (potentiation) of Gene_expression (expression) of SAT1 associated with antagonist
3) Confidence 0.36 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.05
Butaprost-mediated SAT1 gene expression is potentiated by G?
Positive_regulation (mediated) of Gene_expression (expression) of SAT1 gene
4) Confidence 0.36 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
We investigated the integrative signaling mediating the role of prostanoids on SAT1 expression in FPEP2 cells.
Spec (investigated) Positive_regulation (mediating) of Gene_expression (expression) of SAT1
5) Confidence 0.36 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.38 Pain Relevance 0.03
As shown in Fig. 4A, Butaprost treatment alone significantly increased expression of SAT1 at all time points compared to vehicle treatment (P < 0.001).
Positive_regulation (increased) of Gene_expression (expression) of SAT1
6) Confidence 0.36 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.03
For example SAT1 gene expression was enhanced from a 5.9 fold increase to a 7.5 fold increase, whereas cytochrome P450, family 26, subfamily A, polypeptide 1 (CYP26A1) gene expression was repressed from an 18.0 fold increase to a 12.3 fold increase.
Positive_regulation (enhanced) of Gene_expression (expression) of SAT1 gene
7) Confidence 0.36 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
Butaprost-mediated SAT1 gene expression is potentiated by G?
Positive_regulation (potentiated) of Gene_expression (expression) of SAT1 gene
8) Confidence 0.36 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
However, co-stimulation of FPEP2 cells with Butaprost and PGF enhanced the Butaprost-stimulated expression of SAT1 significantly at all time points (P < 0.001).
Positive_regulation (stimulated) of Gene_expression (expression) of SAT1
9) Confidence 0.36 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.04
A transgenic increase of SAT1 expression in mice showed a variety of defects such as hair loss, female infertility, impaired lipid metabolism and predisposition to develop pancreatitis [36].
Positive_regulation (increase) of Gene_expression (expression) of SAT1 in hair associated with targeted disruption, pancreatitis, female infertility and alopecia
10) Confidence 0.33 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.77 Pain Relevance 0

General Comments

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