INT289738

Context Info Confidence 0.31 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.93 Pain Relevance 0.21

intracellular (Sat1) transferase activity, transferring acyl groups (Sat1) cytoplasm (Sat1)

Sat1 (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 33 94.84 Dismenorea 3 61.60 endometriosis 3 60.40 fibrosis 3 58.04 Kinase C 33 5.00 adenocard 6 5.00 imagery 3 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 9 89.04 Alopecia 3 82.40 Female Infertility 3 81.52 Pancreatitis 3 75.44 Intestinal Cancer 6 65.36 Reprotox - General 1 6 61.60 Endometriosis (extended) 18 60.40 Fibrosis 3 58.04 Cancer 3 54.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As shown in Fig. 4B, antagonism of the FP receptor completely abolished the potentiation of SAT1 expression by PGF without altering Butaprost-stimulated expression of SAT1.

Negative_regulation (abolished) of Gene_expression (expression) of SAT1

1) Confidence 0.31 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.05

As shown in Fig. 4C, ablation of AC3 expression reduced SAT1 mRNA expression in FPEP2 cells treated with the combination of Butaprost and PGF to the level observed following stimulation with Butaprost alone (P < 0.001).

Negative_regulation (reduced) of Gene_expression (expression) of SAT1 mRNA

2) Confidence 0.31 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.24 Pain Relevance 0.13

q cross-talk via AC3, such that siRNA knockdown of the AC3 isoform completely inhibited the potentiation of Butaprost-stimulated SAT1 expression by PGF.

Negative_regulation (inhibited) of Gene_expression (expression) of SAT1

3) Confidence 0.30 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.69 Pain Relevance 0.03

General Comments

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