INT289779

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) cell adhesion (Comp)
proteinaceous extracellular matrix (Comp) extracellular matrix organization (Comp)
Anatomy Link Frequency
ligament 3
muscle 3
cartilage 1
tendon 1
Comp (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 16 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tendinopathy 20 82.36 Quite High
Stress 96 82.00 Quite High
Muscle Disease 116 79.28 Quite High
Apoptosis 12 71.28 Quite High
Disease 12 48.52 Quite Low
Muscle Weakness 44 42.56 Quite Low
Osteochondrodysplasias 156 36.24 Quite Low
Sprains And Strains 56 5.00 Very Low Very Low Very Low
Joint Instability 40 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown that Comp is expressed in murine tendon and ligament by a variety of techniques, and that the localization of mutant COMP was not altered in mutant tissues.
Neg (not) Regulation (altered) of Localization (localization) of COMP in ligament
1) Confidence 0.39 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.22 Pain Relevance 0
Interestingly, these observations are in direct contrast to changes in the localization of mutant COMP seen in the cartilage growth plates of Comp T585M mutant mice (20) and suggests that the ECM of muscle and cartilage may assemble and respond differently to the presence of mutant COMP.
Regulation (changes) of Localization (localization) of COMP in muscle
2) Confidence 0.23 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.42 Pain Relevance 0
We have shown that Comp is expressed in murine tendon and ligament by a variety of techniques, and that the localization of mutant COMP was not altered in mutant tissues.
Neg (not) Regulation (altered) of in tendon Localization (localization) of COMP in ligament
3) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.22 Pain Relevance 0
Interestingly, these observations are in direct contrast to changes in the localization of mutant COMP seen in the cartilage growth plates of Comp T585M mutant mice (20) and suggests that the ECM of muscle and cartilage may assemble and respond differently to the presence of mutant COMP.
Regulation (changes) of in cartilage Localization (localization) of COMP in muscle
4) Confidence 0.08 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.42 Pain Relevance 0

General Comments

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