INT289783

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.70
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5) nucleus (Hspa5)
response to stress (Hspa5)
Anatomy Link Frequency
reticulum 1
growth plate 1
Hspa5 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 95.16 Very High Very High Very High
Stress 25 94.60 High High
Death 2 90.96 High High
Sprains And Strains 14 66.44 Quite High
Muscle Disease 29 50.00 Quite Low
Tendinopathy 5 50.00 Quite Low
Cleidocranial Dysplasia 10 23.04 Low Low
Dwarfism 4 9.60 Low Low
Osteoarthritis 6 7.60 Low Low
Osteochondrodysplasias 39 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of our previous findings in the mutant cartilage growth plate, where BiP was significantly upregulated and Bcl-2 was downregulated (20) owing to the expression of mutant Comp T585M, we considered the possibility that the expression of mutant Comp T585M was eliciting an rER/cell stress response in tenocytes that might eventually be causing increased cell death.
Negative_regulation (downregulated) of BiP in growth plate associated with stress and death
1) Confidence 0.22 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.70 Pain Relevance 0
The 78 kDa glucose-regulated protein is generally regarded as an endoplasmic reticulum protein, however, it has been reported to be present in mitochondrial matrix [29].
Negative_regulation (regarded) of 78 kDa glucose-regulated protein in reticulum
2) Confidence 0.12 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2911678 Disease Relevance 0 Pain Relevance 0

General Comments

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