INT289789

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) Golgi apparatus (Rer1)
cell adhesion (Comp) proteinaceous extracellular matrix (Comp) molecular_function (Rer1)
Anatomy Link Frequency
chondrocytes 2
Comp (Mus musculus)
Rer1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 4 59.84 Quite High
Arthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 24 100.00 Very High Very High Very High
Death 2 99.20 Very High Very High Very High
Osteochondrodysplasias 39 90.16 High High
Osteoarthritis 6 59.84 Quite High
Joint Instability 10 59.08 Quite High
Bone Cancer 2 52.68 Quite High
Cleidocranial Dysplasia 10 51.20 Quite High
Muscle Disease 29 50.00 Quite Low
Tendinopathy 5 50.00 Quite Low
Dwarfism 4 43.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extensive research over the last 10 years has demonstrated that mutant COMP protein harbouring structural changes in the type 3 repeats is retained within patient chondrocytes, eventually resulting in rER stress and increased cell death both in vitro and in vivo (reviewed in 18).
COMP protein Positive_regulation (resulting) of Gene_expression (stress) of rER in chondrocytes associated with stress and death
1) Confidence 0.55 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.80 Pain Relevance 0.03

General Comments

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