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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.59
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp, Fn1) cell adhesion (Comp, Fn1) proteinaceous extracellular matrix (Comp, Fn1)
extracellular matrix organization (Comp, Fn1) extracellular region (Comp)
Anatomy Link Frequency
Comp (Mus musculus)
Fn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 6 85.56 High High
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Action potential 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteochondrodysplasias 66 94.64 High High
Death 3 92.36 High High
Stress 29 91.76 High High
Osteoarthritis 13 85.56 High High
Joint Instability 11 84.80 Quite High
Bone Cancer 4 78.40 Quite High
Cleidocranial Dysplasia 19 76.92 Quite High
Disease 19 71.92 Quite High
Dwarfism 4 69.32 Quite High
Genu Valgum 1 63.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, COMP interacts with numerous ECM proteins including types I, II, IX, XI and XII collagen, decorin, fibronectin and matrilin-3 (11–15), and a role for COMP as a catalyst in collagen fibrillogenesis has been proposed (16).
COMP Spec (proposed) Binding (interacts) of fibronectin in ECM
1) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 1.20 Pain Relevance 0.12
Furthermore, in the cartilage extracellular matrix COMP plays a bridging role and is able to interact with other ECM molecules such as matrilin-3, type IX collagen, aggrecan, fibronectin, and integrins [62–65].
COMP Binding (interact) of fibronectin in extracellular matrix
2) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 1.39 Pain Relevance 0

General Comments

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