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Context Info
Confidence 0.28
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.67
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr3b)
Htr3b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 6 100.00 Very High Very High Very High
Clonidine 5 97.00 Very High Very High Very High
Dopamine 1 96.16 Very High Very High Very High
Pain 4 95.92 Very High Very High Very High
agonist 3 95.44 Very High Very High Very High
anesthesia 2 94.92 High High
Opioid 1 91.76 High High
Eae 1 88.44 High High
sodium channel 2 51.68 Quite High
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myalgia 8 99.60 Very High Very High Very High
Syndrome 2 99.14 Very High Very High Very High
Post-operative Nausea 2 98.80 Very High Very High Very High
Vomiting 3 96.84 Very High Very High Very High
Pain 2 95.92 Very High Very High Very High
Nociception 2 94.32 High High
Hypotension 1 77.16 Quite High
Hypertension 18 50.00 Quite Low
Heart Rate Under Development 19 48.96 Quite Low
Coronary Heart Disease 3 38.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Do variations in the 5-HT3A and 5-HT3B serotonin receptor genes (HTR3A and HTR3B) influence the occurrence of postoperative vomiting?
HTR3B Binding (variations) of associated with post-operative nausea and serotonin
1) Confidence 0.28 Published 2009 Journal Anesth. Analg. Section Title Doc Link 19713259 Disease Relevance 0.47 Pain Relevance 0.32
Gene ontology analysis then revealed that most of the 65 known genes were related to "metal ion binding", "protein binding", or "synaptic transmission" functions, and some of these presented "receptor/transporter/channel activity", some of which have an ion channel activity (Chrna5, Chrna3, Chrnb4, Htr3a, Htr3b, Fxyd2, and Hcn4).
Htr3b Binding (binding) of
2) Confidence 0.26 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1865373 Disease Relevance 0 Pain Relevance 0.05
SNPs in the HTR3B and HTR7 genes, rs2276307 and rs1935349, respectively, were significantly associated with the myalgia score.
HTR3B Binding (associated) of associated with myalgia
3) Confidence 0.20 Published 2007 Journal Muscle Nerve Section Abstract Doc Link 17600820 Disease Relevance 0.94 Pain Relevance 0.26
The high dose of B-HT 933 necessary to begin to mimic the effects of clonidine, a finding consistent with some studies using B-HT 933 in adults, suggests that the wall-climbing syndrome is mediated by receptors which have a low affinity for B-HT 933.
B-HT 933 Binding (affinity) of associated with syndrome and clonidine
4) Confidence 0.19 Published 1987 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2819900 Disease Relevance 0.26 Pain Relevance 0.64

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