INT289835

Context Info Confidence 0.96 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0.03

cell proliferation (LRP2) endosome (LRP2) small molecule metabolic process (LRP2) Golgi apparatus (LRP2) endoplasmic reticulum (LRP2) plasma membrane (LRP2)

LRP2 (Homo sapiens)

Pain Link Frequency Relevance Heat Hippocampus 1 60.00 fibrosis 7 5.28 gABA 4 5.00 Glutamate 2 5.00 fluoxetine 1 5.00 adenocard 1 5.00 antidepressant 1 5.00 medulla 1 5.00

Disease Link Frequency Relevance Heat Familial Hypophosphatemia 1 94.20 Kidney Stones 2 93.32 Nephrocalcinosis 1 81.72 Renal Failure 1 80.84 Targeted Disruption 6 80.48 Congenital Anomalies 2 44.72 Kyphosis 1 31.76 Pressure And Volume Under Development 8 26.56 Disease 1 6.92 Cystic Fibrosis 7 5.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Lack of degradation of megalin and PTH in mice lacking ClC-5 is believed to lead to a high luminal concentration of these calcitropic proteins, resulting in microalbuminuria, hyperphosphaturia and hypercalciuria [93].

Protein_catabolism (degradation) of megalin associated with familial hypophosphatemia and kidney stones

1) Confidence 0.96 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792346 Disease Relevance 0.58 Pain Relevance 0.03

General Comments

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