INT289835

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Context Info
Confidence 0.96
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LRP2) endosome (LRP2) small molecule metabolic process (LRP2)
Golgi apparatus (LRP2) endoplasmic reticulum (LRP2) plasma membrane (LRP2)
LRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 1 60.00 Quite High
fibrosis 7 5.28 Low Low
gABA 4 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
antidepressant 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Hypophosphatemia 1 94.20 High High
Kidney Stones 2 93.32 High High
Nephrocalcinosis 1 81.72 Quite High
Renal Failure 1 80.84 Quite High
Targeted Disruption 6 80.48 Quite High
Congenital Anomalies 2 44.72 Quite Low
Kyphosis 1 31.76 Quite Low
Pressure And Volume Under Development 8 26.56 Quite Low
Disease 1 6.92 Low Low
Cystic Fibrosis 7 5.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lack of degradation of megalin and PTH in mice lacking ClC-5 is believed to lead to a high luminal concentration of these calcitropic proteins, resulting in microalbuminuria, hyperphosphaturia and hypercalciuria [93].
Protein_catabolism (degradation) of megalin associated with familial hypophosphatemia and kidney stones
1) Confidence 0.96 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792346 Disease Relevance 0.58 Pain Relevance 0.03

General Comments

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