INT289959

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD28, CD80) cytosol (CD28) intracellular (CD80)
cell-cell signaling (CD80)
Anatomy Link Frequency
plaque 2
CD28 (Homo sapiens)
CD80 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 68 92.88 High High
abatacept 2 53.72 Quite High
Inflammation 7 9.08 Low Low
cytokine 26 5.00 Very Low Very Low Very Low
Infliximab 15 5.00 Very Low Very Low Very Low
Etanercept 13 5.00 Very Low Very Low Very Low
Adalimumab 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 76 92.88 High High
Leukocytosis 1 33.20 Quite Low
INFLAMMATION 6 9.08 Low Low
Disease 15 5.00 Very Low Very Low Very Low
Mycobacterial Infection 8 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Demyelinating Disease 5 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IDEC-114 blocks the CD28/CD80 co-stimulatory interaction which is an activation signal without affecting the CTLA4/CD80 interaction which is the deactivation signal.[2728] In a phase I open label study, 24 patients with severe plaque psoriasis received one single IV infusion of 0.05, 1, 5, 10, or 15 mg/kg IDEC-114.
Negative_regulation (blocks) of CD28 Binding (interaction) of CD80 in plaque associated with psoriasis
1) Confidence 0.07 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.24 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox