INT289989

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.85
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Narf)
Narf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 12 98.96 Very High Very High Very High
agonist 44 91.28 High High
Clonidine 16 77.04 Quite High
headache 8 71.44 Quite High
beta blocker 8 49.68 Quite Low
Onset of action 12 48.28 Quite Low
metalloproteinase 4 27.20 Quite Low
depression 4 14.68 Low Low
Paresthesia 4 12.92 Low Low
Glutamate 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 360 100.00 Very High Very High Very High
INFLAMMATION 12 98.96 Very High Very High Very High
Glaucoma 320 98.28 Very High Very High Very High
Adverse Drug Reaction 4 95.92 Very High Very High Very High
Hypotension 36 93.92 High High
Hypersensitivity 20 92.56 High High
Pruritus 8 71.56 Quite High
Headache 8 71.44 Quite High
Conjunctivitis 12 70.44 Quite High
Corneal Edema 4 65.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At high doses, they can induce increased IOP.
Positive_regulation (increased) of IOP associated with ocular hypertension
1) Confidence 0.02 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792620 Disease Relevance 0.85 Pain Relevance 0.08
In a double-masked, placebo-controlled trial, brimonidine was effective in reducing the IOP in patients with elevated IOP.
Positive_regulation (elevated) of IOP associated with ocular hypertension
2) Confidence 0.02 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792620 Disease Relevance 1.04 Pain Relevance 0.11
It is indicated for short-term use for the prevention or control of post-surgical increases in IOP, and indicated as an adjunctive agent for POAG.
Positive_regulation (increases) of IOP associated with glaucoma and ocular hypertension
3) Confidence 0.02 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792620 Disease Relevance 1.11 Pain Relevance 0.46
At high doses, they can induce increased IOP.
Positive_regulation (induce) of IOP associated with ocular hypertension
4) Confidence 0.02 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792620 Disease Relevance 0.85 Pain Relevance 0.08

General Comments

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