INT289990

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.77 Pain Relevance 0

nucleus (Narf)

Narf (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 6 28.80 agonist 11 18.72 Glutamate 8 5.00 Clonidine 4 5.00 Inflammation 3 5.00 Onset of action 3 5.00 beta blocker 2 5.00 nMDA receptor 2 5.00 cytokine 2 5.00 headache 2 5.00

Disease Link Frequency Relevance Heat Ocular Hypertension 90 100.00 Hypotension 9 84.84 Age-related Macular Degeneration 3 62.12 Open-angle Glaucoma 3 35.28 Glaucoma 80 22.32 Apoptosis 11 5.00 Blindness 8 5.00 Ganglion Cysts 6 5.00 Hypersensitivity 5 5.00 Heart Rate Under Development 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The addition of latanoprost to timolol treatment produces an additional IOP reduction of 13-37%, depending upon the frequency of the application and the baseline IOP.

Positive_regulation (depending) of Gene_expression (produces) of IOP associated with ocular hypertension

1) Confidence 0.02 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792620 Disease Relevance 0.77 Pain Relevance 0

General Comments

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