INT29
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
At luminal pH 7 adrenergic blockade with phentolamine and propranolol reduced vagally stimulated gastrin by 60%. | |||||||||||||||
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Blockade of opiate receptors by naloxone had no effect on vagal gastrin release, however, the noncholinergic gastrin response was reduced significantly by naloxone, suggesting that cholinergic mechanisms normally restrain activation of endogenous opioids during vagal stimulation. | |||||||||||||||
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Atropine reduced vagally stimulated gastrin levels substantially. | |||||||||||||||
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Our results indicate that capsaicin-sensitive afferent neurons participate in the secretion of gastrin by luminal alkalization and inhibition of gastrin by luminal acidification. | |||||||||||||||
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It is suggested that one of the mechanisms of enkephalin analog protective action might involve the prevention of the gastrin increased level. | |||||||||||||||
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M&B 28,767 (3-15 micrograms/kg/h) and DMPG (3-60 micrograms/kg/h) reduced GAS in a dose-related manner, the ED50 values being 4 and 15 micrograms/kg/h respectively. | |||||||||||||||
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Finally a decrease in gastrin serum levels was observed after the i.v. administration of Pirenzepine and this could be explained by a possible effect of blockade of this drug on the cholinergic receptors of the antral G cells, but these data need further experimental confirm. | |||||||||||||||
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Gastric acid inhibition after a single dose of PG was most pronounced in the first hour of a test meal and was accompanied by almost complete suppression of the meal-induced serum gastrin level. | |||||||||||||||
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Further studies with these animal models have to show whether effects seen by vaccination could be mediated by induction of gastrin suppression and studies on human tissues are necessary to show possible similar effects with H.P. | |||||||||||||||
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The results show specific significant gastrin suppression after immunization and antigen feeding. | |||||||||||||||
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A decreasing pepsinogen A-C ratio and pepsinogen A level are known to reflect an increasing severity of corpus atrophy, whereas gastrin levels decrease with an increasing severity of antral atrophy when corpus atrophy is present. | |||||||||||||||
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Both basal and acetylcholine-stimulated gastrin were inhibited by GLP-1 (7-36) amide but were not influenced by GLP-1 (1-36) amide. | |||||||||||||||
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In conscious rats possessing indwelling gastric cannulae, oral doses of M&B 28,767 (0.025-0.1 microgram/kg) and DMPG (0.50-1.0 microgram/kg) caused a prolonged inhibition of pentagastrin-stimulated GAS. | |||||||||||||||
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In this same area, IHC revealed modest reductions in CCK, gastrin, and substance P staining. | |||||||||||||||
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Resiniferatoxin administered in low concentrations like capsaicin produced a similar dose-dependent inhibition of GAS. | |||||||||||||||
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In patients with metastatic disease who had high levels of gastrin, SMS treatment for 5 to 12 months did not inhibit tumor growth or decrease gastrin levels. | |||||||||||||||
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Treatment for up to 12 months with SMS 201-995 controlled symptoms in six of eight patients, suppressed serum gastrin in three of five, and suppressed acid secretion in three of three patients. | |||||||||||||||
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Gastrin levels were decreased on day 1, 3 and 10 (ANOVA; p < 0.01). | |||||||||||||||
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Inhibition of gastrin- and histamine-stimulated gastric acid secretion by gastrin and cholecystokinin antagonists in the rat. | |||||||||||||||
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Neuronal expression of Fos protein in the brain after intravenous injection of gastrin in rats. | |||||||||||||||
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General Comments
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