INT29

Context Info Confidence 0.59 First Reported 1976 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 74 Total Number 75 Disease Relevance 24.85 Pain Relevance 24.96

signal transduction (Gast) extracellular region (Gast)

Anatomy Link Frequency plasma 3 gastric juice 2 afferent neurons 2 capsules 1 duodenum 1 Gast (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 131 100.00 Somatostatin 122 100.00 Cholecystokinin 102 100.00 anesthesia 62 100.00 substance P 14 100.00 Migraine 3 100.00 Cluster headache 3 100.00 tetrodotoxin 16 99.96 Calcitonin gene-related peptide 34 99.90 qutenza 35 99.30

Disease Link Frequency Relevance Heat Pain 164 100.00 Headache 5 100.00 Cluster Headache 3 100.00 Post-operative Nausea 76 99.80 Cancer 56 99.78 Ulcers 83 99.76 Immunization 8 99.72 Duodenal Ulcer 17 99.56 Diarrhoea 14 99.38 INFLAMMATION 14 99.28

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Mutation

Event

Anatomy

Negation

Speculation

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Disease term

At luminal pH 7 adrenergic blockade with phentolamine and propranolol reduced vagally stimulated gastrin by 60%.

Negative_regulation (reduced) of gastrin

1) Confidence 0.59 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.63

Blockade of opiate receptors by naloxone had no effect on vagal gastrin release, however, the noncholinergic gastrin response was reduced significantly by naloxone, suggesting that cholinergic mechanisms normally restrain activation of endogenous opioids during vagal stimulation.

Negative_regulation (reduced) of gastrin associated with endogenous opioid, narcan and opiate

2) Confidence 0.59 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.83

Atropine reduced vagally stimulated gastrin levels substantially.

Negative_regulation (reduced) of gastrin

3) Confidence 0.59 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.46

Our results indicate that capsaicin-sensitive afferent neurons participate in the secretion of gastrin by luminal alkalization and inhibition of gastrin by luminal acidification.

Negative_regulation (inhibition) of gastrin in afferent neurons associated with qutenza

4) Confidence 0.59 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877240 Disease Relevance 0 Pain Relevance 0.66

It is suggested that one of the mechanisms of enkephalin analog protective action might involve the prevention of the gastrin increased level.

Negative_regulation (prevention) of gastrin associated with enkephalin

5) Confidence 0.58 Published 1982 Journal Biull Eksp Biol Med Section Abstract Doc Link 7115528 Disease Relevance 0.43 Pain Relevance 0.35

M&B 28,767 (3-15 micrograms/kg/h) and DMPG (3-60 micrograms/kg/h) reduced GAS in a dose-related manner, the ED50 values being 4 and 15 micrograms/kg/h respectively.

Negative_regulation (reduced) of GAS

6) Confidence 0.58 Published 1984 Journal Life Sci. Section Abstract Doc Link 6513724 Disease Relevance 0.07 Pain Relevance 0

Finally a decrease in gastrin serum levels was observed after the i.v. administration of Pirenzepine and this could be explained by a possible effect of blockade of this drug on the cholinergic receptors of the antral G cells, but these data need further experimental confirm.

Negative_regulation (decrease) of gastrin in G cells

7) Confidence 0.58 Published 1982 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6957988 Disease Relevance 0.25 Pain Relevance 0.20

Gastric acid inhibition after a single dose of PG was most pronounced in the first hour of a test meal and was accompanied by almost complete suppression of the meal-induced serum gastrin level.

Negative_regulation (suppression) of gastrin

8) Confidence 0.58 Published 1979 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 395627 Disease Relevance 0.15 Pain Relevance 0

Further studies with these animal models have to show whether effects seen by vaccination could be mediated by induction of gastrin suppression and studies on human tissues are necessary to show possible similar effects with H.P.

Negative_regulation (suppression) of gastrin

9) Confidence 0.57 Published 1999 Journal Eur. J. Med. Res. Section Abstract Doc Link 10425267 Disease Relevance 0.37 Pain Relevance 0

The results show specific significant gastrin suppression after immunization and antigen feeding.

Negative_regulation (suppression) of gastrin associated with immunization

10) Confidence 0.57 Published 1999 Journal Eur. J. Med. Res. Section Abstract Doc Link 10425267 Disease Relevance 0.85 Pain Relevance 0.06

A decreasing pepsinogen A-C ratio and pepsinogen A level are known to reflect an increasing severity of corpus atrophy, whereas gastrin levels decrease with an increasing severity of antral atrophy when corpus atrophy is present.

Negative_regulation (decrease) of gastrin in corpus

11) Confidence 0.55 Published 1996 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 8900906 Disease Relevance 0.26 Pain Relevance 0

Both basal and acetylcholine-stimulated gastrin were inhibited by GLP-1 (7-36) amide but were not influenced by GLP-1 (1-36) amide.

Negative_regulation (inhibited) of gastrin

12) Confidence 0.52 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 1972810 Disease Relevance 0 Pain Relevance 0.39

In conscious rats possessing indwelling gastric cannulae, oral doses of M&B 28,767 (0.025-0.1 microgram/kg) and DMPG (0.50-1.0 microgram/kg) caused a prolonged inhibition of pentagastrin-stimulated GAS.

Negative_regulation (inhibition) of GAS

13) Confidence 0.51 Published 1984 Journal Life Sci. Section Abstract Doc Link 6513724 Disease Relevance 0.20 Pain Relevance 0.06

In this same area, IHC revealed modest reductions in CCK, gastrin, and substance P staining.

Negative_regulation (reductions) of gastrin associated with cholecystokinin and substance p

14) Confidence 0.50 Published 1992 Journal J. Comp. Neurol. Section Abstract Doc Link 1479068 Disease Relevance 0 Pain Relevance 0.77

Resiniferatoxin administered in low concentrations like capsaicin produced a similar dose-dependent inhibition of GAS.

Negative_regulation (inhibition) of GAS associated with qutenza

15) Confidence 0.49 Published 1995 Journal Pharmacol. Res. Section Abstract Doc Link 8685071 Disease Relevance 0 Pain Relevance 0.60

In patients with metastatic disease who had high levels of gastrin, SMS treatment for 5 to 12 months did not inhibit tumor growth or decrease gastrin levels.

Negative_regulation (decrease) of gastrin associated with cancer and metastasis

16) Confidence 0.46 Published 1988 Journal Surgery Section Abstract Doc Link 2903562 Disease Relevance 0.99 Pain Relevance 0.18

Treatment for up to 12 months with SMS 201-995 controlled symptoms in six of eight patients, suppressed serum gastrin in three of five, and suppressed acid secretion in three of three patients.

Negative_regulation (suppressed) of gastrin

17) Confidence 0.46 Published 1988 Journal Surgery Section Abstract Doc Link 2903562 Disease Relevance 0.76 Pain Relevance 0.11

Gastrin levels were decreased on day 1, 3 and 10 (ANOVA; p < 0.01).

Negative_regulation (decreased) of Gastrin

18) Confidence 0.44 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10087452 Disease Relevance 0 Pain Relevance 0.47

Inhibition of gastrin- and histamine-stimulated gastric acid secretion by gastrin and cholecystokinin antagonists in the rat.

Negative_regulation (Inhibition) of gastrin associated with antagonist and cholecystokinin

19) Confidence 0.43 Published 1991 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 1932479 Disease Relevance 0 Pain Relevance 0.32

Neuronal expression of Fos protein in the brain after intravenous injection of gastrin in rats.

Negative_regulation (injection) of gastrin in Neuronal

20) Confidence 0.43 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 11755239 Disease Relevance 0 Pain Relevance 0.22

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