INT290026

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 2
Speculated 2
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 6.61
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG) mitochondrion (CHDH) enzyme binding (PPARG)
DNA binding (PPARG) lipid metabolic process (PPARG) cytoplasm (PPARG)
Anatomy Link Frequency
heart 1
PPARG (Homo sapiens)
CHDH (Homo sapiens)
PPARG - P12A (1)
Pain Link Frequency Relevance Heat
Angina 28 16.00 Low Low
alcohol 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 350 100.00 Very High Very High Very High
Obesity 91 99.42 Very High Very High Very High
Metabolic Syndrome 7 93.00 High High
Overweight 63 91.52 High High
Body Weight 7 85.64 High High
Hypertension 42 80.00 Quite High
Diabetes Mellitus 56 74.52 Quite High
Metabolic Disorder 7 67.32 Quite High
Myocardial Infarction 35 61.76 Quite High
Atherosclerotic Plaque 7 61.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, there was no major consistent association between the PPARG C-681G, C-689T, Pro12Ala, and C1431T genotypes or related haplotypes and CHD risk.
PPARG Neg (no) Binding (association) of CHD associated with coronary artery disease
1) Confidence 0.10 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.73 Pain Relevance 0
In the present study, which has a similar number of cases and controls, we found no evidence for such a relationship, suggesting that obesity is not a determinant of the association between PPARG genetic variability and CHD.

5.

PPARG Binding (association) of CHD associated with coronary artery disease and obesity
2) Confidence 0.10 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 0.74 Pain Relevance 0
In conclusion, the PPARG Ala12Ala genotype might be associated with a higher CHD risk in men but further confirmation studies are needed.


1.

PPARG Spec (might) Binding (associated) of CHD associated with coronary artery disease
3) Confidence 0.10 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2792957 Disease Relevance 0.48 Pain Relevance 0
In the present study, we did not find any consistent association between the PPARG C-681G, C-689T, Pro12Ala, or C1431T SNPs or related haplotypes and CHD risk, neither in men nor in women, in the PRIME and ADVANCE studies.
PPARG Neg (neither) Binding (association) of CHD associated with coronary artery disease
4) Confidence 0.10 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 1.06 Pain Relevance 0
Therefore, the goal of the present study was to explore the association between 4 PPARG SNPs, including the Pro12Ala SNP, and CHD risk in two independent studies among white subjects.
PPARG Binding (association) of CHD associated with coronary artery disease
5) Confidence 0.09 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 1.21 Pain Relevance 0
Early studies analyzed the association between the PPARG Pro12Ala SNP and coronary heart disease (CHD) in cohorts from North America.
PPARG (P12A) Spec (analyzed) Binding (association) of CHD in heart associated with coronary artery disease
6) Confidence 0.09 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 1.16 Pain Relevance 0
Therefore, the goal of the present study was to explore the association between 4 PPARG SNPs, including the Pro12Ala SNP, and CHD risk in two independent studies among white subjects.
PPARG Binding (association) of CHD associated with coronary artery disease
7) Confidence 0.09 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 1.21 Pain Relevance 0

General Comments

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