INT290075

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (RAB27A) protein targeting (RAB27A) Golgi apparatus (RAB27A)
GTPase activity (RAB27A) lysosome (RAB27A)
RAB27A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 73 93.68 High High
Choroideremia 166 89.60 High High
Experimental Melanoma 1 79.92 Quite High
Targeted Disruption 4 67.68 Quite High
Disease 13 59.76 Quite High
Cancer 47 56.16 Quite High
Metastasis 13 42.72 Quite Low
Aggression 2 21.92 Low Low
Blindness 1 11.72 Low Low
Skin Cancer 2 7.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They suggested that the lack of rep-1 alters the rab27a/myosin7a complex that in turn affects RPE phagocytosis [15].
Regulation (alters) of rab27a
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.73 Pain Relevance 0
Thirty-five of the genes in our 96-gene invasion signature are known or predicted targets of MITF [18], and although experimentally confirmed MITF targets such as MLANA, RAB27A, and GPR143 corresponded closely with MITF expression in our data, some did not, suggesting a disconnect in MITF signalling for some MITF targets in certain melanomas.
Regulation (targets) of RAB27A associated with melanoma
2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.58 Pain Relevance 0

General Comments

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