INT290078

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.30
Pain Relevance 0.07

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signal transduction (WNT5A) extracellular space (WNT5A) extracellular region (WNT5A)
proteinaceous extracellular matrix (WNT5A) plasma membrane (WNT5A) embryo development (WNT5A)
Anatomy Link Frequency
monocytes 1
fibroblasts 1
WNT5A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 18 73.04 Quite High
imagery 15 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 9 100.00 Very High Very High Very High
Muscular Dystrophy 6 100.00 Very High Very High Very High
Choroideremia 498 99.52 Very High Very High Very High
Stress 15 47.52 Quite Low
Disease 30 5.00 Very Low Very Low Very Low
Age-related Macular Degeneration 12 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Toxicity 9 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Retina Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional categories affected in both fibroblasts and monocytes of CHM patients included a large group of genes involved in regulation of cell adhesion and motility (NCAM-2, FMN1, ANKRD28, CSF3R, DMD, MLLT4, DPP4, TSPAN5, CD114, DMD, CYFIP2, WNT5A, MMP7), immune response (IL1, CC2, CFI, ELOVL2), regulation of trafficking and exocytosis (RGS11, SYT 6, GBF1) and transcriptional regulation (HOXD11, MRO, NRG1, NLRC3, NR2F6, SALL1, DIP2A, RSOPO2) (Fig. 7A).
Regulation (regulation) of WNT5A in monocytes associated with muscular dystrophy, choroideremia and adhesions
1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.80 Pain Relevance 0
Interestingly, expression levels of genes encoding secreted proteins from different functional groups including CFI, CC2, NRG1, MMP7, WNT5A, RSOPO2, CSF3R, DPP4, IL1 were deregulated altered in CHM cells compared to the control.
Regulation (deregulated) of WNT5A associated with choroideremia
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.70 Pain Relevance 0.07
Functional categories affected in both fibroblasts and monocytes of CHM patients included a large group of genes involved in regulation of cell adhesion and motility (NCAM-2, FMN1, ANKRD28, CSF3R, DMD, MLLT4, DPP4, TSPAN5, CD114, DMD, CYFIP2, WNT5A, MMP7), immune response (IL1, CC2, CFI, ELOVL2), regulation of trafficking and exocytosis (RGS11, SYT 6, GBF1) and transcriptional regulation (HOXD11, MRO, NRG1, NLRC3, NR2F6, SALL1, DIP2A, RSOPO2) (Fig. 7A).
Regulation (regulation) of WNT5A in fibroblasts associated with muscular dystrophy, choroideremia and adhesions
3) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.80 Pain Relevance 0

General Comments

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