INT290081

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.24
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NRG1) extracellular space (NRG1) extracellular region (NRG1)
plasma membrane (NRG1) nucleus (NRG1) embryo development (NRG1)
Anatomy Link Frequency
monocytes 2
fibroblasts 2
NRG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 7 93.84 High High
Neurotransmitter 1 84.64 Quite High
Glutamate 1 78.88 Quite High
gABA 1 74.56 Quite High
cytokine 30 73.04 Quite High
interneuron 1 69.92 Quite High
GABAergic 2 59.64 Quite High
cannabis 1 51.44 Quite High
Hippocampus 15 48.00 Quite Low
imagery 28 37.44 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 15 100.00 Very High Very High Very High
Muscular Dystrophy 10 100.00 Very High Very High Very High
Schizophrenia 50 99.84 Very High Very High Very High
Choroideremia 830 99.52 Very High Very High Very High
Urological Neuroanatomy 2 83.36 Quite High
Psychosis 4 79.44 Quite High
Disease 54 78.72 Quite High
Syndrome 1 70.32 Quite High
Intrauterine Growth Retardation 1 63.96 Quite High
Stress 25 47.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although a full survey is beyond the scope of this review, the ultimate etiology of schizophrenia may be related to disturbances in regulation of trophic genes such as neuregulin or dysbindin (Norton et al. 2006), neurochemical alterations (Boks et al. 2007), or adverse environmental events (Byrne et al. 2007; Muller & Schwarz 2006).
Regulation (regulation) of neuregulin associated with schizophrenia
1) Confidence 0.26 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012441 Disease Relevance 0.68 Pain Relevance 0.27
Functional categories affected in both fibroblasts and monocytes of CHM patients included a large group of genes involved in regulation of cell adhesion and motility (NCAM-2, FMN1, ANKRD28, CSF3R, DMD, MLLT4, DPP4, TSPAN5, CD114, DMD, CYFIP2, WNT5A, MMP7), immune response (IL1, CC2, CFI, ELOVL2), regulation of trafficking and exocytosis (RGS11, SYT 6, GBF1) and transcriptional regulation (HOXD11, MRO, NRG1, NLRC3, NR2F6, SALL1, DIP2A, RSOPO2) (Fig. 7A).
Regulation (regulation) of NRG1 in monocytes associated with muscular dystrophy, choroideremia and adhesions
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.88 Pain Relevance 0.03
Functional categories affected in both fibroblasts and monocytes of CHM patients included a large group of genes involved in regulation of cell adhesion and motility (NCAM-2, FMN1, ANKRD28, CSF3R, DMD, MLLT4, DPP4, TSPAN5, CD114, DMD, CYFIP2, WNT5A, MMP7), immune response (IL1, CC2, CFI, ELOVL2), regulation of trafficking and exocytosis (RGS11, SYT 6, GBF1) and transcriptional regulation (HOXD11, MRO, NRG1, NLRC3, NR2F6, SALL1, DIP2A, RSOPO2) (Fig. 7A).
Regulation (regulation) of NRG1 in monocytes associated with muscular dystrophy, choroideremia and adhesions
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.72 Pain Relevance 0.03
Interestingly, expression levels of genes encoding secreted proteins from different functional groups including CFI, CC2, NRG1, MMP7, WNT5A, RSOPO2, CSF3R, DPP4, IL1 were deregulated altered in CHM cells compared to the control.
Regulation (deregulated) of NRG1 associated with choroideremia
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.70 Pain Relevance 0.07
Furthermore, altered expression of other genes such as nuclear orphan transcription factor Nur-related receptor 1 (Nurr1) (Xing et al. 2006) or Neuregulin 1 is altered in schizophrenia (Harrison and Law 2006; Addington et al. 2007).
Regulation (altered) of Neuregulin 1 associated with schizophrenia
5) Confidence 0.02 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2871377 Disease Relevance 0.68 Pain Relevance 0.14
Functional categories affected in both fibroblasts and monocytes of CHM patients included a large group of genes involved in regulation of cell adhesion and motility (NCAM-2, FMN1, ANKRD28, CSF3R, DMD, MLLT4, DPP4, TSPAN5, CD114, DMD, CYFIP2, WNT5A, MMP7), immune response (IL1, CC2, CFI, ELOVL2), regulation of trafficking and exocytosis (RGS11, SYT 6, GBF1) and transcriptional regulation (HOXD11, MRO, NRG1, NLRC3, NR2F6, SALL1, DIP2A, RSOPO2) (Fig. 7A).
Regulation (regulation) of NRG1 in fibroblasts associated with muscular dystrophy, choroideremia and adhesions
6) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.72 Pain Relevance 0.03
Functional categories affected in both fibroblasts and monocytes of CHM patients included a large group of genes involved in regulation of cell adhesion and motility (NCAM-2, FMN1, ANKRD28, CSF3R, DMD, MLLT4, DPP4, TSPAN5, CD114, DMD, CYFIP2, WNT5A, MMP7), immune response (IL1, CC2, CFI, ELOVL2), regulation of trafficking and exocytosis (RGS11, SYT 6, GBF1) and transcriptional regulation (HOXD11, MRO, NRG1, NLRC3, NR2F6, SALL1, DIP2A, RSOPO2) (Fig. 7A).
Regulation (regulation) of NRG1 in fibroblasts associated with muscular dystrophy, choroideremia and adhesions
7) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.88 Pain Relevance 0.03

General Comments

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