INT290096

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.21
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NRG1) extracellular space (NRG1) extracellular region (NRG1)
plasma membrane (NRG1) nucleus (NRG1) embryo development (NRG1)
NRG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 2 93.84 High High
cytokine 6 73.04 Quite High
interneuron 2 69.92 Quite High
GABAergic 4 64.88 Quite High
Hippocampus 26 48.00 Quite Low
imagery 9 42.68 Quite Low
anesthesia 7 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
primary somatosensory cortex 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 18 99.84 Very High Very High Very High
Choroideremia 166 99.52 Very High Very High Very High
Muscular Dystrophy 2 90.40 High High
Urological Neuroanatomy 2 88.60 High High
Adhesions 3 87.16 High High
Disease 12 83.96 Quite High
Syndrome 2 75.56 Quite High
Intrauterine Growth Retardation 2 69.20 Quite High
Congenital Anomalies 6 44.60 Quite Low
Stress 5 33.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, expression levels of genes encoding secreted proteins from different functional groups including CFI, CC2, NRG1, MMP7, WNT5A, RSOPO2, CSF3R, DPP4, IL1 were deregulated altered in CHM cells compared to the control.
Regulation (deregulated) of Gene_expression (expression) of NRG1 associated with choroideremia
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.78 Pain Relevance 0.07
Furthermore, altered expression of other genes such as nuclear orphan transcription factor Nur-related receptor 1 (Nurr1) (Xing et al. 2006) or Neuregulin 1 is altered in schizophrenia (Harrison and Law 2006; Addington et al. 2007).
Regulation (altered) of Gene_expression (expression) of Neuregulin 1 associated with schizophrenia
2) Confidence 0.02 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2871377 Disease Relevance 0.71 Pain Relevance 0.14
Furthermore, altered expression of other genes such as nuclear orphan transcription factor Nur-related receptor 1 (Nurr1) (Xing et al. 2006) or Neuregulin 1 is altered in schizophrenia (Harrison and Law 2006; Addington et al. 2007).
Regulation (altered) of Gene_expression (expression) of Neuregulin 1 associated with schizophrenia
3) Confidence 0.02 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2871377 Disease Relevance 0.71 Pain Relevance 0.14

General Comments

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