INT29020

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Context Info
Confidence 0.45
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 3.50
Pain Relevance 6.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 5
capillary 2
cortex 2
blood 1
pcp (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 12 100.00 Very High Very High Very High
Morphine 28 99.50 Very High Very High Very High
Pain 10 99.40 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 8 99.18 Very High Very High Very High
Potency 3 98.68 Very High Very High Very High
fortral 7 98.06 Very High Very High Very High
antagonist 19 96.80 Very High Very High Very High
Eae 7 95.96 Very High Very High Very High
Calcium channel 3 94.12 High High
ischemia 4 93.92 High High
Disease Link Frequency Relevance Heat
Pain 12 99.40 Very High Very High Very High
Ataxia 2 99.36 Very High Very High Very High
Shock 11 96.48 Very High Very High Very High
Coronary Artery Disease 6 94.80 High High
Body Weight 15 93.60 High High
Hypokinesia 4 93.44 High High
Schizophrenia 3 91.04 High High
Death 44 83.24 Quite High
Natriuresis 2 78.20 Quite High
Pathologic Constriction 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, has been considered as a potentially specific PCP antagonist.
Positive_regulation (population) of PCP in brain associated with antagonist
1) Confidence 0.45 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2820762 Disease Relevance 0.07 Pain Relevance 0.15
During the last four and two weeks of life, pain and other symptom control as reasons for PCP referral were found to be significant factors associated with greater total transitions suggesting patients in the PCP inpatient unit and other acute care hospital wards are more in need of this form of care.
Positive_regulation (reasons) of PCP associated with pain
2) Confidence 0.43 Published 2006 Journal BMC Palliat Care Section Body Doc Link PMC1557663 Disease Relevance 0.80 Pain Relevance 0.33
CONCLUSION: This procedure decreases the incidence of physical activity-induced PCP, without increasing the risks of sensory changes.


Positive_regulation (induced) of PCP
3) Confidence 0.43 Published 2010 Journal Hernia Section Body Doc Link 19826895 Disease Relevance 0.14 Pain Relevance 0
Similar to the results from the studies involving PCP treatment on P2 or on P7, there were no significant differences between groups on the early post-weaning 1 hr locomotor activity test including indices of altered emotionality, or on any of the measures from the sensorimotor battery (data not shown).
Positive_regulation (treatment) of PCP associated with eae
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.29 Pain Relevance 0.08
The half-lives of PCP in serum and brain were increased by the concurrent administration of morphine.
Positive_regulation (increased) of PCP in brain associated with morphine
5) Confidence 0.38 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842396 Disease Relevance 0.17 Pain Relevance 1.15
Morphine elicited a dose-related increase in the duration of phencyclidine (PCP)-induced motor incoordination.
Positive_regulation (increase) of PCP associated with ataxia and morphine
6) Confidence 0.38 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842396 Disease Relevance 0.10 Pain Relevance 0.78
Data are reported which indicate that the ability of verapamil to potentiate PCP's behavioral effects stems from an alteration of the pharmacokinetics of PCP; when verapamil (20 mg/kg, IP) was administered 15 minutes before [3H]PCP (40 microCi/kg, IP), brain levels of tritium were increased by 154 to 225 percent.
Positive_regulation (increased) of PCP in brain
7) Confidence 0.34 Published 1987 Journal Physiol. Behav. Section Abstract Doc Link 3671549 Disease Relevance 0 Pain Relevance 0.13
Naltrexone (1.0 or 4.0 mg/kg) attenuated slightly the PCP-like stimulus effects of SKF 10047 and dextrorphan, but increased PCP-appropriate responding with l- and dl-cyclazocine and levorphanol by enabling higher doses of these drugs to be tested without disruption of responding.
Positive_regulation (increased) of PCP
8) Confidence 0.34 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6813889 Disease Relevance 0 Pain Relevance 0.65
Decreases in cyclazocine choices in the presence of naltrexone were associated with increases in PCP choices.
Positive_regulation (increases) of PCP
9) Confidence 0.24 Published 1983 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6408661 Disease Relevance 0 Pain Relevance 0.48
Pretreatment with THC instead of CBD could similarly increase brain levels of cocaine, PCP, and CBD, although with a lower potency than CBD.
Positive_regulation (increase) of PCP in brain associated with potency and cocaine
10) Confidence 0.15 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331071 Disease Relevance 0 Pain Relevance 0.52
Although CBD pretreatment increased blood and brain levels of cocaine comparably, blood levels of PCP were only modestly elevated (up to 50%).
Positive_regulation (elevated) of PCP in brain associated with cocaine
11) Confidence 0.15 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331071 Disease Relevance 0 Pain Relevance 0.46
ANP secretion during PTCA was higher in patients with concomitant increase in pulmonary capillary pressure (PCP) but was also observed without an increase of PCP, suggesting ventricular ANP secretion.
Neg (without) Positive_regulation (increase) of PCP in capillary associated with percutaneous transluminal coronary angioplasty
12) Confidence 0.15 Published 1993 Journal Angiology Section Abstract Doc Link 8457078 Disease Relevance 0.66 Pain Relevance 0.32
ANP secretion during PTCA was higher in patients with concomitant increase in pulmonary capillary pressure (PCP) but was also observed without an increase of PCP, suggesting ventricular ANP secretion.
Positive_regulation (increase) of PCP in capillary associated with percutaneous transluminal coronary angioplasty
13) Confidence 0.08 Published 1993 Journal Angiology Section Abstract Doc Link 8457078 Disease Relevance 0.68 Pain Relevance 0.33
Brains were sectioned (100 mu m) and presence of the hsp7O gene protein product, HSP7O, was determined immunocytochemically. (+)-3-PPP significantly (0 <0.05) diminished the ability of rimcazole to inhibit PCP hsp7O induction in the retrosplenial cortex. (+)-Cyclazocine (15mg/kg, IP) and (+)-pentazocine (8Omg/kg, IP) given in an analogous manner did not diminish the ability of rimcazole to inhibit PCP hsp7O induction.
Positive_regulation (induction) of PCP hsp7O in cortex associated with fortral
14) Confidence 0.05 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 9138745 Disease Relevance 0.13 Pain Relevance 0.21
An antipsychotic drug, rimcazole, inhibits PCP hsp7O induction.
Positive_regulation (induction) of PCP hsp7O
15) Confidence 0.05 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 9138745 Disease Relevance 0.19 Pain Relevance 0.13
Although CBD pretreatment increased blood and brain levels of cocaine comparably, blood levels of PCP were only modestly elevated (up to 50%).
Positive_regulation (elevated) of PCP in blood associated with cocaine
16) Confidence 0.05 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331071 Disease Relevance 0 Pain Relevance 0.46
Brains were sectioned (100 mu m) and presence of the hsp7O gene protein product, HSP7O, was determined immunocytochemically. (+)-3-PPP significantly (0 <0.05) diminished the ability of rimcazole to inhibit PCP hsp7O induction in the retrosplenial cortex. (+)-Cyclazocine (15mg/kg, IP) and (+)-pentazocine (8Omg/kg, IP) given in an analogous manner did not diminish the ability of rimcazole to inhibit PCP hsp7O induction.
Positive_regulation (induction) of PCP hsp7O in cortex associated with fortral
17) Confidence 0.04 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 9138745 Disease Relevance 0.11 Pain Relevance 0.20
It is also possible that quality interactions with their PCP increased patientsÂ’ trust to see other providers.
Positive_regulation (increased) of PCP
18) Confidence 0.02 Published 2007 Journal J Gen Intern Med Section Body Doc Link PMC2150619 Disease Relevance 0.15 Pain Relevance 0

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